Phenotypes associated with this allele

• Allele Symbol: Setd3^{tm1.1(NCOM)Mfgc}
• Allele Name: targeted mutation 1.1, Mammalian Functional Genomics Centre
• Allele ID: MGI:5766145
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Setd3^tm1.1(NCOM)Mfgc/Setd3^tm1.1(NCOM)Mfgc	C57BL/6N-Setd3^tm1.1(NCOM)Mfgc/Tcp	MGI:5797805
hm2	Setd3^tm1.1(NCOM)Mfgc/Setd3^tm1.1(NCOM)Mfgc	C57BL/6N-Setd3^tm1.1(NCOM)Mfgc/Tcp	MGI:6295503
hm3	Setd3^tm1.1(NCOM)Mfgc/Setd3^tm1.1(NCOM)Mfgc	involves: C57BL/6NCrl	MGI:6452978

Genotype
MGI:5797805

hm1

• Allelic Composition: Setd3^{tm1.1(NCOM)Mfgc}/Setd3^{tm1.1(NCOM)Mfgc}
• Genetic Background: C57BL/6N-Setd3^{tm1.1(NCOM)Mfgc}/Tcp
• Cell Lines: N01803P1_C_167W_D5

Data Sources

IMPC Data for Setd3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased freezing behavior ( J:211773 )

♂

IMPC - TCP

hyperactivity ( J:211773 )

♂

IMPC - TCP

cardiovascular system

shortened QT interval ( J:211773 )

IMPC - TCP

endocrine/exocrine glands

abnormal seminal vesicle morphology ( J:211773 )

♂

IMPC - TCP

abnormal pancreas morphology ( J:211773 )

♀

IMPC - TCP

small testis ( J:211773 )

♂

IMPC - TCP

growth/size/body

decreased body length ( J:211773 )

♂

IMPC - TCP

hematopoietic system

increased leukocyte cell number ( J:211773 )

IMPC - TCP

increased lymphocyte cell number ( J:211773 )

♂

IMPC - TCP

immune system

increased leukocyte cell number ( J:211773 )

IMPC - TCP

increased lymphocyte cell number ( J:211773 )

♂

IMPC - TCP

limbs/digits/tail

short tibia ( J:211773 )

IMPC - TCP

nervous system

decreased prepulse inhibition ( J:211773 )

♂

IMPC - TCP

reproductive system

abnormal seminal vesicle morphology ( J:211773 )

♂

IMPC - TCP

small testis ( J:211773 )

♂

IMPC - TCP

hydrometra ( J:211773 )

♀

IMPC - TCP

skeleton

short tibia ( J:211773 )

IMPC - TCP

vertebral fusion ( J:211773 )

IMPC - TCP

increased bone mineral content ( J:211773 )

♀

IMPC - TCP

increased bone mineral density ( J:211773 )

♀

IMPC - TCP

Genotype
MGI:6295503

hm2

• Allelic Composition: Setd3^{tm1.1(NCOM)Mfgc}/Setd3^{tm1.1(NCOM)Mfgc}
• Genetic Background: C57BL/6N-Setd3^{tm1.1(NCOM)Mfgc}/Tcp

reproductive system

dystocia ( J:270048 )

♀ • primary dystocia in 8 of 9 female mice independent of embryo genotype

♀ • mice are refractory to oxytocin unlike wild-type mice

decreased litter size ( J:270048 )

♀ • produced from female mice

cellular

decreased cell migration ( J:270048 )

• in mouse embryonic fibroblasts

abnormal DNA methylation ( J:270048 )

• mouse embryonic fibroblasts lack actin-His73me methylation

muscle

muscle phenotype ( J:270048 )

N • muscles from young adults exhibit normal gross histopathology

Genotype
MGI:6452978

hm3

• Allelic Composition: Setd3^{tm1.1(NCOM)Mfgc}/Setd3^{tm1.1(NCOM)Mfgc}
• Genetic Background: involves: C57BL/6NCrl

immune system

decreased susceptibility to Riboviria infection ( J:293475 )

• no symptoms and severe reduction in viral load after intracerebral injection of CV-A10 or EV-A71 virus

• mild symptoms and barely detectable viral load after intramuscular injection of EV-D68 virus