Phenotypes associated with this allele

• Allele Symbol: Aire^{tm1.1(NCOM)Mfgc}
• Allele Name: targeted mutation 1.1, Mammalian Functional Genomics Centre
• Allele ID: MGI:5766149
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aire^tm1.1(NCOM)Mfgc/Aire^tm1.1(NCOM)Mfgc	C57BL/6N-Aire^tm1.1(NCOM)Mfgc/Tcp	MGI:5797350
ht2	Aire^tm1.1(NCOM)Mfgc/Aire^+	C57BL/6N-Aire^tm1.1(NCOM)Mfgc/Tcp	MGI:6461049

Genotype
MGI:5797350

hm1

• Allelic Composition: Aire^{tm1.1(NCOM)Mfgc}/Aire^{tm1.1(NCOM)Mfgc}
• Genetic Background: C57BL/6N-Aire^{tm1.1(NCOM)Mfgc}/Tcp
• Cell Lines: N01619P1_C_151W_E1

Data Sources

IMPC Data for Aire

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased monocyte cell number ( J:211773 )

♀

IMPC - TCP

immune system

increased monocyte cell number ( J:211773 )

♀

IMPC - TCP

nervous system

decreased prepulse inhibition ( J:211773 )

♂

IMPC - TCP

vision/eye

abnormal eye morphology ( J:211773 )

IMPC - TCP

abnormal retina morphology ( J:211773 )

IMPC - TCP

Genotype
MGI:6461049

ht2

• Allelic Composition: Aire^{tm1.1(NCOM)Mfgc}/Aire⁺
• Genetic Background: C57BL/6N-Aire^{tm1.1(NCOM)Mfgc}/Tcp
• Cell Lines: N01619P1_C_151W_E1

Data Sources

IMPC Data for Aire

homeostasis/metabolism

abnormal cholesterol homeostasis ( J:211773 )

♀

IMPC - TCP