Phenotypes associated with this allele

• Allele Symbol: Laptm4b^{tm1e.1(KOMP)Wtsi}
• Allele Name: targeted mutation 1e.1, Wellcome Trust Sanger Institute
• Allele ID: MGI:5766156
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Laptm4b^tm1e.1(KOMP)Wtsi/Laptm4b^tm1e.1(KOMP)Wtsi	C57BL/6N-Laptm4b^tm1e.1(KOMP)Wtsi/Tcp	MGI:5797626
ht2	Laptm4b^tm1e.1(KOMP)Wtsi/Laptm4b^+	C57BL/6N-Laptm4b^tm1e.1(KOMP)Wtsi/Tcp	MGI:5797625

Genotype
MGI:5797626

hm1

• Allelic Composition: Laptm4b^{tm1e.1(KOMP)Wtsi}/Laptm4b^{tm1e.1(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Laptm4b^{tm1e.1(KOMP)Wtsi}/Tcp
• Cell Lines: EPD0740_1_E06

Data Sources

IMPC Data for Laptm4b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal craniofacial morphology ( J:211773 )

IMPC - TCP

embryo

abnormal embryo size ( J:211773 )

IMPC - TCP

abnormal neural tube closure ( J:211773 )

IMPC - TCP

growth/size/body

abnormal embryo size ( J:211773 )

IMPC - TCP

homeostasis/metabolism

edema ( J:211773 )

IMPC - TCP

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

♀

IMPC - TCP

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - TCP

nervous system

abnormal neural tube closure ( J:211773 )

IMPC - TCP

abnormal midbrain morphology ( J:211773 )

IMPC - TCP

abnormal hindbrain morphology ( J:211773 )

IMPC - TCP

vision/eye

abnormal eye morphology ( J:211773 )

IMPC - TCP

Genotype
MGI:5797625

ht2

• Allelic Composition: Laptm4b^{tm1e.1(KOMP)Wtsi}/Laptm4b⁺
• Genetic Background: C57BL/6N-Laptm4b^{tm1e.1(KOMP)Wtsi}/Tcp
• Cell Lines: EPD0740_1_E06

Data Sources

IMPC Data for Laptm4b

behavior/neurological

increased startle reflex ( J:211773 )

♀

IMPC - TCP

nervous system

decreased prepulse inhibition ( J:211773 )

♀

IMPC - TCP