Phenotypes associated with this allele

• Allele Symbol: Piezo1^tm2.1Apat
• Allele Name: targeted mutation 2.1, Ardem Patapoutian
• Allele ID: MGI:5766345
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Piezo1^tm2.1Apat/Piezo1^tm2.1Apat Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6 * C57BL/10 * CBA	MGI:5776602

Genotype
MGI:5776602

cn1

• Allelic Composition: Piezo1^tm2.1Apat/Piezo1^tm2.1Apat; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: involves: C57BL/6 * C57BL/10 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased erythrocyte cell number ( J:229436 )

decreased hematocrit ( J:229436 )

increased mean corpuscular hemoglobin ( J:229436 )

decreased mean corpuscular hemoglobin concentration ( J:229436 )

increased mean corpuscular volume ( J:229436 )

increased red blood cell distribution width ( J:229436 )

macrocytosis ( J:229436 )

abnormal spleen morphology ( J:229436 )

• spleens appear dark and redder than controls

abnormal splenic cell ratio ( J:229436 )

• spleens contain an increased number of mature, but not immature, Ter119+, CD71- red blood cells

abnormal erythrocyte ion transport ( J:229436 )

• Ca²⁺ influx is not detectable in red blood cells under negative pressure stimulation in contrast to controls in which intracellular Ca²⁺ is increased

increased erythrocyte osmotic fragility ( J:229436 )

• red blood cells exhibit increased osmotic fragility

homeostasis/metabolism

abnormal erythrocyte ion transport ( J:229436 )

• Ca²⁺ influx is not detectable in red blood cells under negative pressure stimulation in contrast to controls in which intracellular Ca²⁺ is increased

decreased blood osmolality ( J:229436 )

• red blood cells are overhydrated, however, discoid morphology is normal

decreased circulating haptoglobin level ( J:229436 )

• decreased plasma haptoglobin concentration

abnormal calcium ion homeostasis ( J:229436 )

• Ca²⁺ influx is not detectable in red blood cells under negative pressure stimulation in contrast to controls in which intracellular Ca²⁺ is increased

immune system

abnormal spleen morphology ( J:229436 )

• spleens appear dark and redder than controls

abnormal splenic cell ratio ( J:229436 )

• spleens contain an increased number of mature, but not immature, Ter119+, CD71- red blood cells