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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mad2l2tm1Mpz
targeted mutation 1, Mehdi Pirouz
MGI:5769977
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mad2l2tm1Mpz/Mad2l2tm1Mpz
Tg(Prdm1-cre)1Masu/0 		involves: 129S2/SvPas * C57BL/6 * CBA MGI:5769978


Genotype
MGI:5769978
cn1
Allelic
Composition		 Mad2l2tm1Mpz/Mad2l2tm1Mpz
Tg(Prdm1-cre)1Masu/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mad2l2tm1Mpz mutation (0 available); any Mad2l2 mutation (15 available)
Tg(Prdm1-cre)1Masu mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Intrinsic failure of Mad2l2tm1Mpz/Mad2l2tm1Mpz Tg(Prdm1-cre)1Masu/0 primordial germ cells

cellular
abnormal primordial germ cell apoptosis ( J:223048 )
• TUNEL analysis showed apoptosis of some SSEA1-positive PGCs in E8.75 hindgut endoderm
• in addition, TUNEL-positive, SSEA1-negative cells with a high nuclear to cytoplasmic ratio are observed in the hindgut

reproductive system
abnormal primordial germ cell apoptosis ( J:223048 )
• TUNEL analysis showed apoptosis of some SSEA1-positive PGCs in E8.75 hindgut endoderm
• in addition, TUNEL-positive, SSEA1-negative cells with a high nuclear to cytoplasmic ratio are observed in the hindgut




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory