Phenotypes associated with this allele

• Allele Symbol: Mir125a^tm1Smoc
• Allele Name: targeted mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:5770229
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir125a^tm1Smoc/Mir125a^tm1Smoc	involves: C57BL/6	MGI:5770253

Genotype
MGI:5770253

hm1

• Allelic Composition: Mir125a^tm1Smoc/Mir125a^tm1Smoc
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:224880 )

N • mice exhibit normal numbers of T (including TH1, 2 and 17), B and myeloid lineages in the peripheral lymph nodes or spleens at 6 to 8 weeks of age

decreased regulatory T cell number ( J:224880 )

abnormal regulatory T cell physiology ( J:224880 )

• regulatory T cells transferred into Rag1 knock-out mice with naive T cells fail to prevent colitis as well as wild-type regulatory T cells

increased interferon-gamma secretion ( J:224880 )

• in splenocyte cultures of MOG-treated mice

increased interleukin-17 secretion ( J:224880 )

• in splenocyte cultures of MOG-treated mice

increased susceptibility to experimental autoimmune encephalomyelitis ( J:224880 )

• MOG-treated mice exhibit increased clinical score and inflammation compared with wild-type mice

hematopoietic system

decreased regulatory T cell number ( J:224880 )

abnormal regulatory T cell physiology ( J:224880 )

• regulatory T cells transferred into Rag1 knock-out mice with naive T cells fail to prevent colitis as well as wild-type regulatory T cells