Phenotypes associated with this allele

• Allele Symbol: Stk38^tm1Xen
• Allele Name: targeted mutation 1, Taconic Biosciences
• Allele ID: MGI:5770366
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stk38^tm1Xen/Stk38^tm1Xen	involves: 129S5/SvEvBrd * C57BL/6	MGI:5770378

Genotype
MGI:5770378

hm1

• Allelic Composition: Stk38^tm1Xen/Stk38^tm1Xen
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:224932 )

• 80% of mice die after E. coli infection unlike wild-type mice within 18 hours

• 60% of mice die after E. coli infection unlike wild-type mice after 30 hours

increased susceptibility to induced morbidity/mortality ( J:224932 )

• following cecal ligation and puncture surgery

immune system

immune system phenotype ( J:224932 )

N • mice exhibit normal LPS- and LTA-induced TNFalpha and IL6 production in peritoneal macrophages

increased circulating interleukin-6 level ( J:224932 )

• in E. coli-infected mice or following intraperitoneal CpG injection

• however, levels are normal after thioglycollate treatment and LPS challenge

increased circulating tumor necrosis factor level ( J:224932 )

• in E. coli-infected mice or following intraperitoneal CpG injection

• however, levels are normal after thioglycollate treatment and LPS challenge

increased interleukin-6 secretion ( J:224932 )

• from CpG-induced peritoneal macrophage

increased tumor necrosis factor secretion ( J:224932 )

• from CpG-induced peritoneal macrophage

increased susceptibility to bacterial infection ( J:224932 )

• E. coli-infected mice exhibit increased serum TNFalpha and IL6 concentration and increased mortality compared with wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:224932 )

• 80% of mice die after E. coli infection unlike wild-type mice within 18 hours

• 60% of mice die after E. coli infection unlike wild-type mice after 30 hours

homeostasis/metabolism

increased circulating interleukin-6 level ( J:224932 )

• in E. coli-infected mice or following intraperitoneal CpG injection

• however, levels are normal after thioglycollate treatment and LPS challenge

increased circulating tumor necrosis factor level ( J:224932 )

• in E. coli-infected mice or following intraperitoneal CpG injection

• however, levels are normal after thioglycollate treatment and LPS challenge

increased susceptibility to injury ( J:224932 )

• following cecal ligation and puncture surgery, mice exhibit worse disease scores with earlier and increased mortality compared with wild-type mice