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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmem203tm1.1Roml
targeted mutation 1.1, Mark A Labow
MGI:5770432
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmem203tm1.1Roml/Tmem203tm1.1Roml involves: C57BL/6 MGI:5770444


Genotype
MGI:5770444
hm1
Allelic
Composition		 Tmem203tm1.1Roml/Tmem203tm1.1Roml
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem203tm1.1Roml mutation (0 available); any Tmem203 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:222925 )
N
• male mice exhibit normal prostate gland, seminal vesicle, epididymides, serum testosterone, follicle stimulating hormone and luteinizing hormone
abnormal sperm head morphology ( J:222925 )
• abnormal shape
• however, sperm exhibit normal condensation of chromatin and morphology of the acrosome
abnormal testis morphology ( J:222925 )
• testicular cells exhibit altered calcium mobilization compared with wild-type cells
seminiferous tubule degeneration ( J:222925 )
• atrophy is occasionally observed
decreased testis weight ( J:222925 )
• at 24 weeks
abnormal spermiation ( J:222925 )
• arrested at the nuclear condensation stage
• however, meiosis is normal
reduced female fertility ( J:222925 )
• female mice produce fewer litters than wild-type mice

growth/size/body
decreased body weight ( J:222925 )

cellular
abnormal sperm head morphology ( J:222925 )
• abnormal shape
• however, sperm exhibit normal condensation of chromatin and morphology of the acrosome
abnormal endoplasmic reticulum physiology ( J:222925 )
• thapsigargin- or m-3mFBS-treated mouse embryonic fibroblasts exhibit reduced total calcium release from the endoplasmic reticulum compared with wild-type cells

endocrine/exocrine glands
abnormal testis morphology ( J:222925 )
• testicular cells exhibit altered calcium mobilization compared with wild-type cells
seminiferous tubule degeneration ( J:222925 )
• atrophy is occasionally observed
decreased testis weight ( J:222925 )
• at 24 weeks




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory