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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ffar2tm2Soff
targeted mutation 2, Stefan Offermanns
MGI:5770447
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ffar2tm2Soff/Ffar2tm2Soff
Ffar3tm2.1Soff/Ffar3tm2.1Soff
Tg(Vil1-cre)997Gum/0
involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL MGI:5770568
cn2
Ffar2tm2Soff/Ffar2tm2Soff
Ffar3tm2.1Soff/Ffar3tm2.1Soff
Tg(Ins2-cre)25Mgn/0
involves: 129S4/SvJae * C57BL/6 * DBA MGI:5770569


Genotype
MGI:5770568
cn1
Allelic
Composition
Ffar2tm2Soff/Ffar2tm2Soff
Ffar3tm2.1Soff/Ffar3tm2.1Soff
Tg(Vil1-cre)997Gum/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ffar2tm2Soff mutation (0 available); any Ffar2 mutation (25 available)
Ffar3tm2.1Soff mutation (0 available); any Ffar3 mutation (18 available)
Tg(Vil1-cre)997Gum mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• plasma insulin levels are normal after acetate treatment
• mice fed a high-fat diet and treated with either intraperitoneal injection or oral glucose challenge exhibit normal glucose tolerance, plasma free fatty acid levels and insulin secretion




Genotype
MGI:5770569
cn2
Allelic
Composition
Ffar2tm2Soff/Ffar2tm2Soff
Ffar3tm2.1Soff/Ffar3tm2.1Soff
Tg(Ins2-cre)25Mgn/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ffar2tm2Soff mutation (0 available); any Ffar2 mutation (25 available)
Ffar3tm2.1Soff mutation (0 available); any Ffar3 mutation (18 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• loss of acetate-induced PTX-sensitive inhibition of glucose stimulated insulin secretion
• in mice fed a high-fat diet
• in mice fed a high-fat diet
• in mice fed a high-fat diet

endocrine/exocrine glands
• loss of acetate-induced PTX-sensitive inhibition of glucose stimulated insulin secretion





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory