Phenotypes associated with this allele

• Allele Symbol: Nabp2^tm1Schg
• Allele Name: targeted mutation 1, Sandy Chang
• Allele ID: MGI:5770467
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nabp2^tm1Schg/Nabp2^tm1Schg	involves: 129S7/SvEvBrd * C57BL/6	MGI:5770580
cx2	Nabp2^tm1Schg/Nabp2^tm1Schg Trp53^tm1Brd/Trp53^tm1Brd	involves: 129S7/SvEvBrd * C57BL/6	MGI:5770583

Genotype
MGI:5770580

hm1

• Allelic Composition: Nabp2^tm1Schg/Nabp2^tm1Schg
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by gamma-irradiation ( J:228558 )

• in mouse embryonic fibroblasts

premature death ( J:228558 )

• median survival 8.6 months for males is and 13 months for females

hematopoietic system

increased spleen red pulp amount ( J:228558 )

• hyperplasia

• however, germinal center appearance is normal

cellular

chromosomal instability ( J:228558 )

• increased chromosomal aberrations in irradiated mouse embryonic fibroblasts

homeostasis/metabolism

increased mortality induced by gamma-irradiation ( J:228558 )

• in mouse embryonic fibroblasts

immune system

increased spleen red pulp amount ( J:228558 )

• hyperplasia

• however, germinal center appearance is normal

Genotype
MGI:5770583

cx2

• Allelic Composition: Nabp2^tm1Schg/Nabp2^tm1Schg; Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

neoplasm

increased lymphoma incidence ( J:228558 )

• disseminated lymphoma in the kidney and liver unlike in Trp53^tm1Brd mice

• however, total cancer incidents are not elevated