Analysis Tools
homeostasis/metabolism
| N |
• when fed normal chow or a high-fat diet, mice exhibit normal basal metabolic rate and energy expenditure
• in hyperinsulinemic-euglycemic clamp experiments, glucose infusion rates are normal
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• loss of acetate-induced PTX-sensitive inhibition of glucose stimulated insulin secretion
• increased insulin secretion exposed to high glucose concentrations in a small volume
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• in mice fed a high-fat diet after a glucose challenge more so than in single knock-outs
• however, mice fed a normal diet exhibit normal insulin levels
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• prolonged drop after glucose challenge in mice fed a high-fat diet
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• mice fed a high-fat diet exhibit a tendency toward improved glucose tolerance compared with control mice
• however, mice fed normal chow exhibit normal glucose tolerance
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endocrine/exocrine glands
| N |
• islets exhibit normal morphology
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• loss of acetate-induced PTX-sensitive inhibition of glucose stimulated insulin secretion
• increased insulin secretion exposed to high glucose concentrations in a small volume
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