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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mc1rtm1.1Mymi
targeted mutation 1.1, Mayumi Ito
MGI:5770883
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(Tyr-cre/ERT2)13Bos/0 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac MGI:6269418
cn2
 		Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(CMV-cre)1Cgn/0 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac MGI:6269420
cn3
 		Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(KRT14-rtTA)F42Efu/0
Tg(tetO-EDN1,-lacZ)9Mhus/0
Tg(Tyr-cre/ERT2)13Bos/0 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB MGI:6269451
cn4
 		Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(CMV-cre)1Cgn/0
Tg(Dct-lacZ)#Ove/0 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB/N MGI:6269442
cn5
 		Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(Dct-lacZ)#Ove/0
Tg(Tyr-cre/ERT2)13Bos/0 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB/N MGI:6269447
cn6
 		Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(Dct-lacZ)#Ove/0
Tg(Krt1-15-cre/PGR*)22Cot/0 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB/N * SJL/J MGI:6269449
cn7
 		Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(Krt1-15-cre/PGR*)22Cot/0 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * SJL/J MGI:6269432


Genotype
MGI:6269418
cn1
Allelic
Composition		 Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(Tyr-cre/ERT2)13Bos/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation (1 available); any Mc1r mutation (44 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:231435 )
• following TAM treatment, mice exhibit a yellow coat color at 2nd telogen, similar to mice homozygous for the Mc1re allele

integument
yellow coat color ( J:231435 )
• following TAM treatment, mice exhibit a yellow coat color at 2nd telogen, similar to mice homozygous for the Mc1re allele




Genotype
MGI:6269420
cn2
Allelic
Composition		 Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(CMV-cre)1Cgn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation (1 available); any Mc1r mutation (44 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
yellow coat color ( J:231435 )
• mice exhibit a yellow coat color at 2nd telogen, similar to mice homozygous for the Mc1re allele

integument
yellow coat color ( J:231435 )
• mice exhibit a yellow coat color at 2nd telogen, similar to mice homozygous for the Mc1re allele




Genotype
MGI:6269451
cn3
Allelic
Composition		 Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(KRT14-rtTA)F42Efu/0
Tg(tetO-EDN1,-lacZ)9Mhus/0
Tg(Tyr-cre/ERT2)13Bos/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation (1 available); any Mc1r mutation (44 available)
Tg(KRT14-rtTA)F42Efu mutation (1 available)
Tg(tetO-EDN1,-lacZ)9Mhus mutation (1 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal epidermal melanocyte morphology ( J:231435 )
• following wounding, mice show a significant increase of epidermal melanocytes containing dark pigment in the wound site, indicating that Edn1 overexpression in epithelial cells can rescue the defect of epidermal melanocyte regeneration caused by MC1R loss in the melanocyte lineage

integument
abnormal epidermal melanocyte morphology ( J:231435 )
• following wounding, mice show a significant increase of epidermal melanocytes containing dark pigment in the wound site, indicating that Edn1 overexpression in epithelial cells can rescue the defect of epidermal melanocyte regeneration caused by MC1R loss in the melanocyte lineage




Genotype
MGI:6269442
cn4
Allelic
Composition		 Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(CMV-cre)1Cgn/0
Tg(Dct-lacZ)#Ove/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation (1 available); any Mc1r mutation (44 available)
Tg(CMV-cre)1Cgn mutation (6 available)
Tg(Dct-lacZ)#Ove mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal epidermal melanocyte morphology ( J:231435 )
• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice

integument
abnormal epidermal melanocyte morphology ( J:231435 )
• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice




Genotype
MGI:6269447
cn5
Allelic
Composition		 Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(Dct-lacZ)#Ove/0
Tg(Tyr-cre/ERT2)13Bos/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation (1 available); any Mc1r mutation (44 available)
Tg(Dct-lacZ)#Ove mutation (0 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal epidermal melanocyte morphology ( J:231435 )
• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice

integument
abnormal epidermal melanocyte morphology ( J:231435 )
• following wounding, mice show a significant reduction of epidermal melanocytes in the wound site relative to control mice




Genotype
MGI:6269449
cn6
Allelic
Composition		 Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(Dct-lacZ)#Ove/0
Tg(Krt1-15-cre/PGR*)22Cot/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * FVB/N * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation (1 available); any Mc1r mutation (44 available)
Tg(Dct-lacZ)#Ove mutation (0 available)
Tg(Krt1-15-cre/PGR*)22Cot mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:231435 )
N
• following wounding, mice show no differences in the recruitment of epidermal melanocytes to the wound area relative to control mice




Genotype
MGI:6269432
cn7
Allelic
Composition		 Mc1rtm1.1Mymi/Mc1rtm1.1Mymi
Tg(Krt1-15-cre/PGR*)22Cot/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mc1rtm1.1Mymi mutation (1 available); any Mc1r mutation (44 available)
Tg(Krt1-15-cre/PGR*)22Cot mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:231435 )
N
• after RU486 treatment, mice exhibit no defects in coat/hair pigmentation at 2nd telogen relative to control mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory