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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln
targeted mutation 1, Nicolas Pilon
MGI:5774458
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+
Tg(T-cre)1Lwd/0 		involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 MGI:5774469
cn2
 		Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+
Tg(Pax3-cre)1Joe/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5774470
cn3
 		Cdx1tm1Pgr/Cdx1tm1Pgr
Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+
Tg(Pax3-cre)1Joe/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5774471
cn4
 		Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+
Pax3Sp/Pax3+
Tg(Pax3-cre)1Joe/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5774472


Genotype
MGI:5774469
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+
Tg(T-cre)1Lwd/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(T-cre)1Lwd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
rib fusion ( J:231654 )
• 33% of mutants show fusion of ribs in the thoracic region
abnormal vertebrae morphology ( J:231654 )
• neonates show vertebral malformations with a higher penetrance at the cervical level than at thoracic and lumber regions
decreased thoracic vertebrae number ( J:231654 )
• reduction in the number of thoracic vertebrae (12 instead of 13)
abnormal cervical vertebrae morphology ( J:231654 )
• absence of the tuberculum anterior on C6
decreased lumbar vertebrae number ( J:231654 )
• some mutants only have five lumbar vertebrae instead of six
abnormal vertebral arch morphology ( J:231654 )
• cervical regions show malformed neural arches
vertebral fusion ( J:231654 )
• neonates show vertebral fusions with a higher penetrance at the cervical level than at thoracic and lumber regions
• cervical vertebra 1 and associated anterior arch of the atlas are fused to the basioccipital bone
vertebral transformation ( J:231654 )
• neonates show the presence of a high number of homeotic transformations
• C2/C3 are anteriorly transformed
cervical vertebral transformation ( J:231654 )
• cervical regions show anterior homeotic transformations




Genotype
MGI:5774470
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+
Tg(Pax3-cre)1Joe/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Pax3-cre)1Joe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:231654 )
• a high number of newborns die at about P1, with very little, if any, milk in their stomach
postnatal lethality, incomplete penetrance ( J:231654 )
• a subset of mutants with severe growth delay die at around P10

behavior/neurological
absent gastric milk in neonates ( J:231654 )
• newborns that die at P1 have very little, if any, milk in their stomachs

growth/size/body
decreased body size ( J:231654 )
postnatal growth retardation ( J:231654 )
• mutants that survive past P2 exhibit severe growth delay

integument
abnormal coat/hair pigmentation ( J:231654 )
• 100% of mice that survive past P2 show pigmentation anomalies
abnormal hind foot hair pigmentation ( J:231654 )
• mice that survive past P2 lack pigmentation in the hindpaws
abnormal tail hair pigmentation ( J:231654 )
• mice that survive past P2 lack pigmentation in the distal tail
belly spot ( J:231654 )
• in about 25% of surviving mice, a tiny white spot is seen on the belly

limbs/digits/tail
kinked tail ( J:231654 )
• half of newborns exhibit a kinked tail

pigmentation
abnormal coat/hair pigmentation ( J:231654 )
• 100% of mice that survive past P2 show pigmentation anomalies
abnormal hind foot hair pigmentation ( J:231654 )
• mice that survive past P2 lack pigmentation in the hindpaws
abnormal tail hair pigmentation ( J:231654 )
• mice that survive past P2 lack pigmentation in the distal tail
belly spot ( J:231654 )
• in about 25% of surviving mice, a tiny white spot is seen on the belly

renal/urinary system
hydronephrosis ( J:231654 )
• about half of mice that die at P10 exhibit hydronephrotic kidney

reproductive system
reduced fertility ( J:231654 )
• mice exhibit reproduction problems




Genotype
MGI:5774471
cn3
Allelic
Composition		 Cdx1tm1Pgr/Cdx1tm1Pgr
Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+
Tg(Pax3-cre)1Joe/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdx1tm1Pgr mutation (1 available); any Cdx1 mutation (13 available)
Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Pax3-cre)1Joe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal melanoblast migration ( J:231654 )
• melanoblasts migrating along the dorsolateral pathway in hindlimb buds are not well aligned in mutants

embryo
abnormal melanoblast migration ( J:231654 )
• melanoblasts migrating along the dorsolateral pathway in hindlimb buds are not well aligned in mutants

integument
white spotting ( J:231654 )
• increase in penetrance and extent of white spotting in the posterior regions

nervous system
abnormal hypoglossal nerve morphology ( J:231654 )
• E10.5 mutants exhibit abnormalities of the hypoglossal nerve, with the converging roots appearing disorganized and less dense and resulting in a reduced number of elongating axons that are shorter
fused dorsal root ganglion ( J:231654 )
• E10.5 embryos exhibit the presence of fusions of dorsal root ganglia in the cervical region

pigmentation
white spotting ( J:231654 )
• increase in penetrance and extent of white spotting in the posterior regions




Genotype
MGI:5774472
cn4
Allelic
Composition		 Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln/Gt(ROSA)26Sor+
Pax3Sp/Pax3+
Tg(Pax3-cre)1Joe/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(en/Cdx1,-EGFP)Npln mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Pax3Sp mutation (4 available); any Pax3 mutation (50 available)
Tg(Pax3-cre)1Joe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
abnormal coat/hair pigmentation ( J:231654 )
• posterior pigmentation anomalies of each single mutant are accentuated in all double mutants
• lack of pigmentation in the forepaws and hindpaws
abnormal tail hair pigmentation ( J:231654 )
• lack of pigmentation in the distal tail

nervous system
abnormal enteric ganglia morphology ( J:231654 )
• mice exhibit hypoganglionosis

pigmentation
abnormal coat/hair pigmentation ( J:231654 )
• posterior pigmentation anomalies of each single mutant are accentuated in all double mutants
• lack of pigmentation in the forepaws and hindpaws
abnormal tail hair pigmentation ( J:231654 )
• lack of pigmentation in the distal tail




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory