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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccr5tm1(CCR5)Pfi
targeted mutation 1, Pfizer, Ltd
MGI:5774771
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccr5tm1(CCR5)Pfi/Ccr5tm1(CCR5)Pfi involves: C57BL/6 MGI:5774772


Genotype
MGI:5774772
hm1
Allelic
Composition		 Ccr5tm1(CCR5)Pfi/Ccr5tm1(CCR5)Pfi
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr5tm1(CCR5)Pfi mutation (0 available); any Ccr5 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:227458 )
N
• mice develop a similar severity of pulmonary hypertension as wild-type mice after 18 days of hypoxia

homeostasis/metabolism
increased physiological sensitivity to xenobiotic ( J:227458 )
• treatment with Maraviroc 200 attenuates but does not fully abrogate hypoxia-induced pulmonary hypertension development in mutants compared to having no effect in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory