Phenotypes associated with this allele

• Allele Symbol: Retreg1^tm1.1Cahb
• Allele Name: targeted mutation 1.1, Christian Hubner
• Allele ID: MGI:5774849
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Retreg1^tm1.1Cahb/Retreg1^tm1.1Cahb	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5774851

Genotype
MGI:5774851

hm1

• Allelic Composition: Retreg1^tm1.1Cahb/Retreg1^tm1.1Cahb
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal sensory neuron morphology ( J:222922 )

• most cultured sensory neurons from 3 month old mice exhibit swollen endoplasmic reticulum compared with wild-type neurons

• sensory neurons from 10 month old mice exhibit endoplasmic reticulum expansion and Golgi cisternae dilation compared with wild-type neurons

• aged mice exhibit reduced sensory axon numbers compared with wild-type mice

neuron degeneration ( J:222922 )

• of peripheral sensory nerves

• however, lower motor neurons are normal

behavior/neurological

increased thermal nociceptive threshold ( J:222922 )