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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Map1am1J
mutation 1, Jackson
MGI:5774956
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Map1am1J/Map1am1J C57BLKS/J-Map1am1J/SlacJ MGI:5774963
ht2
Map1am1J/Map1atm1.2(KOMP)Mbp involves: 129S4/SvJaeSor * C57BL/6N * C57BL/6NJ MGI:5774961
cx3
Map1am1J/Map1am1J
Tg(Map1a)56Pjn/0
involves: C57BL/6J * C57BLKS/J MGI:6756405


Genotype
MGI:5774963
hm1
Allelic
Composition
Map1am1J/Map1am1J
Genetic
Background
C57BLKS/J-Map1am1J/SlacJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map1am1J mutation (1 available); any Map1a mutation (109 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice do not exhibit neuronal death or reactive gliosis in noncerebellar region
• reduced microtubule network
• at 7 months in the cerebellar cortex and by 18 months in the cerebellum
• transgene expression of the LC2 isoform doesnt not rescue Purkinje cell degeneration
• however, no loss is observed prior to 3 months and transgene expression of the precursor gene rescues Purkinje cell loss
• focal swellings beginning at 6 weeks and becoming more widespread with age
• at 18 months of age
• axonal torpedos beginning at 6 weeks of age
• hypertrophic or exhibiting abnormal blebs at 2 months
• transgene expression of the LC2 isoform doesnt not rescue the axon initial segment phenotype

behavior/neurological
• mild




Genotype
MGI:5774961
ht2
Allelic
Composition
Map1am1J/Map1atm1.2(KOMP)Mbp
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6N * C57BL/6NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map1am1J mutation (1 available); any Map1a mutation (109 available)
Map1atm1.2(KOMP)Mbp mutation (0 available); any Map1a mutation (109 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• by 7 months of age without death of other neurons




Genotype
MGI:6756405
cx3
Allelic
Composition
Map1am1J/Map1am1J
Tg(Map1a)56Pjn/0
Genetic
Background
involves: C57BL/6J * C57BLKS/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map1am1J mutation (1 available); any Map1a mutation (109 available)
Tg(Map1a)56Pjn mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• Even at 18 months of age no locomotor defects or Purkinje cell loss was found consistent with transgenic rescue of the homozygous mutant phenotype





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory