All Phenotypes Map1a<m1J> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Map1a^m1J
mutation 1, Jackson
MGI:5774956

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map1a^m1J/Map1a^m1J	C57BLKS/J-Map1a^m1J/SlacJ	MGI:5774963
ht2	Map1a^m1J/Map1a^{tm1.2(KOMP)Mbp}	involves: 129S4/SvJaeSor * C57BL/6N * C57BL/6NJ	MGI:5774961
cx3	Map1a^m1J/Map1a^m1J Tg(Map1a)56Pjn/0	involves: C57BL/6J * C57BLKS/J	MGI:6756405

Allelic Composition	Map1a^m1J/Map1a^m1J
Genetic Background	C57BLKS/J-Map1a^m1J/SlacJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map1a^m1J mutation (1 available); any Map1a mutation (109 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:220153 )

N	• mice do not exhibit neuronal death or reactive gliosis in noncerebellar region

abnormal Purkinje cell morphology ( J:220153 )

• reduced microtubule network

Purkinje cell degeneration ( J:220153 )

• at 7 months in the cerebellar cortex and by 18 months in the cerebellum

• transgene expression of the LC2 isoform doesnt not rescue Purkinje cell degeneration

• however, no loss is observed prior to 3 months and transgene expression of the precursor gene rescues Purkinje cell loss

abnormal Purkinje cell dendrite morphology ( J:220153 )

• focal swellings beginning at 6 weeks and becoming more widespread with age

thin cerebellar molecular layer ( J:220153 )

• at 18 months of age

abnormal axon morphology ( J:220153 )

• axonal torpedos beginning at 6 weeks of age

abnormal axon initial segment morphology ( J:220153 )

• hypertrophic or exhibiting abnormal blebs at 2 months

• transgene expression of the LC2 isoform doesnt not rescue the axon initial segment phenotype

behavior/neurological

ataxia ( J:220153 )

• mild

Allelic Composition	Map1a^m1J/Map1a^{tm1.2(KOMP)Mbp}
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6N * C57BL/6NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map1a^m1J mutation (1 available); any Map1a mutation (109 available)
Map1a^{tm1.2(KOMP)Mbp} mutation (0 available); any Map1a mutation (109 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

Purkinje cell degeneration ( J:220153 )

• by 7 months of age without death of other neurons

Allelic Composition	Map1a^m1J/Map1a^m1J Tg(Map1a)56Pjn/0
Genetic Background	involves: C57BL/6J * C57BLKS/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map1a^m1J mutation (1 available); any Map1a mutation (109 available)
Tg(Map1a)56Pjn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:220153 )

N	• Even at 18 months of age no locomotor defects or Purkinje cell loss was found consistent with transgenic rescue of the homozygous mutant phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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