All Phenotypes Map1a<tm1.2(KOMP)Mbp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Map1a^{tm1.2(KOMP)Mbp}
targeted mutation 1.2, Mouse Biology Program, UC Davis
MGI:5774957

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map1a^{tm1.2(KOMP)Mbp}/Map1a^{tm1.2(KOMP)Mbp}	involves: 129S4/SvJaeSor * C57BL/6N * C57BL/6NJ	MGI:5774960
ht2	Map1a^m1J/Map1a^{tm1.2(KOMP)Mbp}	involves: 129S4/SvJaeSor * C57BL/6N * C57BL/6NJ	MGI:5774961

Allelic Composition	Map1a^{tm1.2(KOMP)Mbp}/Map1a^{tm1.2(KOMP)Mbp}
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6N * C57BL/6NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map1a^{tm1.2(KOMP)Mbp} mutation (0 available); any Map1a mutation (109 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal microtubule cytoskeleton morphology ( J:220153 )

• Purkinje cells have altered levels of particular tubulins and tubulin associated proteins at 18 days and 6 weeks of age

nervous system

Purkinje cell degeneration ( J:220153 )

• by 7 months of age without death of other neurons

abnormal Purkinje cell dendrite morphology ( J:220153 )

• focal swellings beginning at 6 weeks and becoming more widespread with age

abnormal axon initial segment morphology ( J:220153 )

• hypertrophic or exhibiting abnormal blebs at 2 months

Allelic Composition	Map1a^m1J/Map1a^{tm1.2(KOMP)Mbp}
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6N * C57BL/6NJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map1a^m1J mutation (1 available); any Map1a mutation (109 available)
Map1a^{tm1.2(KOMP)Mbp} mutation (0 available); any Map1a mutation (109 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

Purkinje cell degeneration ( J:220153 )

• by 7 months of age without death of other neurons

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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