Phenotypes associated with this allele

• Allele Symbol: Ddx3x^tm1.1Lyou
• Allele Name: targeted mutation 1.1, Li-Ru You
• Allele ID: MGI:5774968
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ddx3x^tm1.1Lyou/Y Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129 * C57BL/6 * CBA	MGI:5774972
cn2	Ddx3x^tm1.1Lyou/Ddx3x^+ Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129 * C57BL/6 * CBA	MGI:5774973

Genotype
MGI:5774972

cn1

• Allelic Composition: Ddx3x^tm1.1Lyou/Y; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: 129 * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:231798 )

♂ • non-viable embryos are detected at E10.5 and E11.5

preweaning lethality, complete penetrance ( J:231798 )

♂ • by weaning no males are detected

embryo

increased embryonic tissue cell apoptosis ( J:231798 )

♂ • in the whole body and allantois before embryo turning

abnormal developmental patterning ( J:231798 )

♂ • deformed caudal embryonic structure at E9.5

abnormal embryo turning ( J:231798 )

♂ • failure of body turning

embryonic growth retardation ( J:231798 )

♂ • developmental delay at E9.5

abnormal head fold morphology ( J:231798 )

♂ • at E9.5

abnormal neural tube closure ( J:231798 )

♂ • defective

abnormal allantois morphology ( J:231798 )

♂ • deformed

small allantois ( J:231798 )

♂ • shorter at E9.5

failure of chorioallantoic fusion ( J:231798 )

♂ • at E8.5 in unturned embryos

cellular

abnormal cell physiology ( J:231798 )

♂ • increase in markers of DNA damage

abnormal cell cycle ( J:231798 )

♂ • cell cycle arrest

increased mitotic index ( J:231798 )

♂ • in embryos at E9.5

increased embryonic tissue cell apoptosis ( J:231798 )

♂ • in the whole body and allantois before embryo turning

cardiovascular system

abnormal myocardial trabeculae morphology ( J:231798 )

♂ • poorly developed

pericardial effusion ( J:231798 )

♂

growth/size/body

embryonic growth retardation ( J:231798 )

♂ • developmental delay at E9.5

microcephaly ( J:231798 )

♂

nervous system

abnormal neural tube closure ( J:231798 )

♂ • defective

abnormal brain development ( J:231798 )

♂ • underdeveloped

homeostasis/metabolism

pericardial effusion ( J:231798 )

♂

muscle

abnormal myocardial trabeculae morphology ( J:231798 )

♂ • poorly developed

Genotype
MGI:5774973

cn2

• Allelic Composition: Ddx3x^tm1.1Lyou/Ddx3x⁺; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: 129 * C57BL/6 * CBA

normal phenotype

no abnormal phenotype detected ( J:231798 )

♀ • females with loss of expression of the maternal allele in the epiblast but not visceral endoderm and extraembryonic ectoderm are viable with no gross abnormalities