Analysis Tools
mortality/aging
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• females with a paternally inherited mutant allele are viable
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• at E16.5-E18.5 the proportion of female embryos with a maternally inherited mutant allele was dramatically reduced to 5/64
• females were readily detected at E13.5 and E14.5
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• by weaning no females with a maternally inherited mutant allele were detected
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embryo
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• at E9.5 fetal blood vessels remain restricted to the chorioallantoic plate regions in females with a maternally inherited mutant allele unlike in wild-type littermate controls
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• vascular network and trophoblast cells in the labyrinth layer are more loosely organized in females with a maternally inherited mutant allele
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• slightly slower growth in females with a maternally inherited mutant allele at E12.5
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• decreased in size at E9.5 in females with a maternally inherited mutant allele
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• at E9.5 in females with a maternally inherited mutant allele
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• decrease in the number of spongiotrophoblast-specific protein alpha-positive cells in the spongiotrophoblast cell layer in females with a maternally inherited mutant allele at E12.5, E14.5 and E16.5
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• in females with a maternally inherited mutant allele at E9.5, E12.5 and E14.5
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• smaller in females with a maternally inherited mutant allele at E12.5
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cardiovascular system
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• at E9.5 fetal blood vessels remain restricted to the chorioallantoic plate regions in females with a maternally inherited mutant allele unlike in wild-type littermate controls
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• vascular network and trophoblast cells in the labyrinth layer are more loosely organized in females with a maternally inherited mutant allele
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• seen at E14.5 and E16.5 in all females with a maternally inherited mutant allele
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hemorrhage
(
J:231798
)
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• peripheral hemorrhage in embryos with small placentas at E14.5 and E16.5
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homeostasis/metabolism
growth/size/body
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• slightly slower growth in females with a maternally inherited mutant allele at E12.5
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