About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		SykM2Btlr
mutation 2, Bruce Beutler
MGI:5775011
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		SykM2Btlr/SykM2Btlr C57BL/6J-SykM2Btlr MGI:5775070
ht2
 		SykM2Btlr/Syk+ C57BL/6J-SykM2Btlr MGI:5775071


Genotype
MGI:5775070
hm1
Allelic
Composition		 SykM2Btlr/SykM2Btlr
Genetic
Background		 C57BL/6J-SykM2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SykM2Btlr mutation (0 available); any Syk mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell differentiation ( J:231803 )
• increased frequencies of natural killer cells in the peripheral blood
decreased inflammatory response ( J:231803 )
• in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment

hematopoietic system
abnormal NK cell differentiation ( J:231803 )
• increased frequencies of natural killer cells in the peripheral blood




Genotype
MGI:5775071
ht2
Allelic
Composition		 SykM2Btlr/Syk+
Genetic
Background		 C57BL/6J-SykM2Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
SykM2Btlr mutation (0 available); any Syk mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal NK cell differentiation ( J:231803 )
• increased frequencies of natural killer cells in the peripheral blood
decreased inflammatory response ( J:231803 )
• in response to priming with lipopolysaccharide (LPS) followed by nigericin treatment

hematopoietic system
abnormal NK cell differentiation ( J:231803 )
• increased frequencies of natural killer cells in the peripheral blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory