All Phenotypes Pgrmc1<tm1.1Jjp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pgrmc1^tm1.1Jjp
targeted mutation 1.1, John J Peluso
MGI:5775088

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pgrmc1^tm1.1Jjp/Pgrmc1^tm1.1Jjp Omp^tm1(cre)Jae/Omp⁺	involves: 129S1/Sv	MGI:5775111
cn2	Pgrmc1^tm1.1Jjp/Pgrmc1^tm1.1Jjp Pgrmc2^tm1.1Jjp/Pgrmc2^tm1.1Jjp Pgr^tm2(cre)Lyd/Pgr⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:6118934
cn3	Pgrmc1^tm1.1Jjp/Pgrmc1^tm1.1Jjp Pgrmc2^tm1.1Jjp/Pgrmc2⁺ Pgr^tm2(cre)Lyd/Pgr⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:6118935

Allelic Composition	Pgrmc1^tm1.1Jjp/Pgrmc1^tm1.1Jjp Omp^tm1(cre)Jae/Omp⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omp^tm1(cre)Jae mutation (0 available); any Omp mutation (27 available)
Pgrmc1^tm1.1Jjp mutation (0 available); any Pgrmc1 mutation (11 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal sensory capabilities/reflexes/nociception ( J:223366 )

• female mice exhibit constant attraction behavior to recombinant major urinary proteins (rMUPs), in both estrus and diestrus unlike wild-type mice

nervous system

nervous system phenotype ( J:223366 )

N	• vomeronasal sensory neurons (VSNs) from ovariectomized mice exhibit normal response to recombinant major urinary proteins (rMUPs), even in the presence of diestrous levels of P4 • VSNs from diestrous-staged female mice exhibit responsiveness to rMUPs across both estrus and diestrus

taste/olfaction

taste/olfaction phenotype ( J:223366 )

N	• vomeronasal sensory neurons (VSNs) from ovariectomized mice exhibit normal response to recombinant major urinary proteins (rMUPs), even in the presence of diestrous levels of P4 • VSNs from diestrous-staged female mice exhibit responsiveness to rMUPs across both estrus and diestrus

Allelic Composition	Pgrmc1^tm1.1Jjp/Pgrmc1^tm1.1Jjp Pgrmc2^tm1.1Jjp/Pgrmc2^tm1.1Jjp Pgr^tm2(cre)Lyd/Pgr⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrmc1^tm1.1Jjp mutation (0 available); any Pgrmc1 mutation (11 available)
Pgrmc2^tm1.1Jjp mutation (0 available); any Pgrmc2 mutation (8 available)
Pgr^tm2(cre)Lyd mutation (0 available); any Pgr mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

early reproductive senescence ( J:247103 )

• in female mice

reproductive system

uterus cyst ( J:247103 )

• in all mice at 4 to 5 months compared with some wild-type mice at 5 to 8 months

early reproductive senescence ( J:247103 )

• in female mice

abnormal endometrium morphology ( J:247103 )

• breakdown of basement membrane and disruption of epithelial-stromal interface

abnormal endometrial gland morphology ( J:247103 )

• vacuolated nuclei, intracellular inclusion bodies and excessive, highly convoluted plasma membrane in glandular epithelial cells

increased endometrial gland number ( J:247103 )

enlarged endometrial glands ( J:247103 )

• enlarged amorphic and cystic glands characteristic of aged endometrium

reduced female fertility ( J:247103 )

• female mice have fewer pups per litter and fewer litters per female compared with control mice

decreased litter size ( J:247103 )

• fewer pups per litter and fewer litters per female

endocrine/exocrine glands

abnormal endometrial gland morphology ( J:247103 )

• vacuolated nuclei, intracellular inclusion bodies and excessive, highly convoluted plasma membrane in glandular epithelial cells

increased endometrial gland number ( J:247103 )

enlarged endometrial glands ( J:247103 )

• enlarged amorphic and cystic glands characteristic of aged endometrium

growth/size/body

uterus cyst ( J:247103 )

• in all mice at 4 to 5 months compared with some wild-type mice at 5 to 8 months

Allelic Composition	Pgrmc1^tm1.1Jjp/Pgrmc1^tm1.1Jjp Pgrmc2^tm1.1Jjp/Pgrmc2⁺ Pgr^tm2(cre)Lyd/Pgr⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

enlarged endometrial glands ( J:247103 )

• enlarged amorphic and cystic glands characteristic of aged endometrium

reproductive system

enlarged endometrial glands ( J:247103 )

• enlarged amorphic and cystic glands characteristic of aged endometrium

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