Analysis Tools
reproductive system
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• individual fetuses from mutant dams are smaller than fetuses from control pregnancies, indicating intrauterine growth restriction
• however, the number of fetal-placental units per pregnancy and placental weights are comparable to controls and no differences in the thickness of the labyrinth or spongiotrophoblast layers are seen
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• dams exhibit renal pathology and dysfunction at the end of gestation, impaired relaxation of conduit arteries in response to acetylcholine, increased blood pressure during pregnancy, and smaller fetus size
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cardiovascular system
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• heart rate is not as elevated in mutant pregnant dams as it is in pregnant controls
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• pregnant females show mildly elevated blood pressure as the normal pregnancy induced reduction in blood pressure is not seen
• however, overt hypertension during pregnancy is not seen
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• conduit arteries (aortae) from pregnant females exhibit impaired relaxation to acetylcholine but normal relaxation response to sodium nitroprusside
• however, second-order branches of mesenteric arteries exhibit normal relaxation responses to both acetylcholine and sodium nitroprusside
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homeostasis/metabolism
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• about 50% increase in urine protein is seen in urine collected from dams on gestational day 17
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muscle
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• conduit arteries (aortae) from pregnant females exhibit impaired relaxation to acetylcholine but normal relaxation response to sodium nitroprusside
• however, second-order branches of mesenteric arteries exhibit normal relaxation responses to both acetylcholine and sodium nitroprusside
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renal/urinary system
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• about 50% increase in urine protein is seen in urine collected from dams on gestational day 17
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• pathognomonic glomerular endotheliosis is seen in dams at the end of gestation
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| pre-eclampsia | DOID:10591 |
OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 OMIM:614592 |
J:229059 | |
