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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zbp1tm1.1Jreh
targeted mutation 1.1, Jan Rehwinkel
MGI:5775152
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zbp1tm1.1Jreh/Zbp1tm1.1Jreh involves: C57BL/6 * C57BL/6N MGI:6107961


Genotype
MGI:6107961
hm1
Allelic
Composition		 Zbp1tm1.1Jreh/Zbp1tm1.1Jreh
Genetic
Background		 involves: C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbp1tm1.1Jreh mutation (0 available); any Zbp1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cell death ( J:252669 )
• cells from mutant mice are resistant to cytomegalovirus (a cytomegalovirus expressing M54 with a mutated RHIM, MCMV-M45mutRHIM)-induced necroptosis

immune system
increased susceptibility to Herpesvirales infection ( J:252669 )
• virus growth of MCMV-M45mutRHIM and accumulation of the viral IE1 protein are enhanced in primary MEFs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory