All Phenotypes Zbp1<tm1.1Jreh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zbp1^tm1.1Jreh
targeted mutation 1.1, Jan Rehwinkel
MGI:5775152

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zbp1^tm1.1Jreh/Zbp1^tm1.1Jreh	involves: C57BL/6 * C57BL/6N	MGI:6107961

Allelic Composition	Zbp1^tm1.1Jreh/Zbp1^tm1.1Jreh
Genetic Background	involves: C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbp1^tm1.1Jreh mutation (0 available); any Zbp1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased cell death ( J:252669 )

• cells from mutant mice are resistant to cytomegalovirus (a cytomegalovirus expressing M54 with a mutated RHIM, MCMV-M45^mutRHIM)-induced necroptosis

immune system

increased susceptibility to Herpesvirales infection ( J:252669 )

• virus growth of MCMV-M45^mutRHIM and accumulation of the viral IE1 protein are enhanced in primary MEFs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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