Phenotypes associated with this allele

• Allele Symbol: Aplnr^tm1.1Path
• Allele Name: targeted mutation 1.1, Patricia A Thistlethwaite
• Allele ID: MGI:5775395
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aplnr^tm1.1Path/Aplnr^tm1.1Path	Not Specified	MGI:5775406

Genotype
MGI:5775406

hm1

• Allelic Composition: Aplnr^tm1.1Path/Aplnr^tm1.1Path
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vein morphology ( J:227456 )

• pulmonary venograms show vessel blunting and absence of peripheral blush

venoocclusion ( J:227456 )

• mice develop pulmonary veno-occlusive disease, with pulmonary venules in all lobes showing narrowing and occlusion

• more than 60% of pulmonary venules are occluded

• however, pulmonary hemorrhage is not seen

heart right ventricle hypertrophy ( J:227456 )

• at 8-10 months of age, mice show evidence of right ventricular hypertrophy

• however, 8-10 month old mice show normal left ventricular dimensions, wall thickness, and fractional shortening, and normal coronary artery and vein anatomy

increased pulmonary artery pressure ( J:227456 )

• by 8 months of age, mice develop elevated pulmonary pressures under ambient oxygen conditions

homeostasis/metabolism

pulmonary edema ( J:227456 )

• mice challenged with the pulmonary vasodilator epoprostenol develop severe pulmonary edema

respiratory system

pulmonary edema ( J:227456 )

• mice challenged with the pulmonary vasodilator epoprostenol develop severe pulmonary edema

muscle

heart right ventricle hypertrophy ( J:227456 )

• at 8-10 months of age, mice show evidence of right ventricular hypertrophy

• however, 8-10 month old mice show normal left ventricular dimensions, wall thickness, and fractional shortening, and normal coronary artery and vein anatomy

growth/size/body

heart right ventricle hypertrophy ( J:227456 )

• at 8-10 months of age, mice show evidence of right ventricular hypertrophy

• however, 8-10 month old mice show normal left ventricular dimensions, wall thickness, and fractional shortening, and normal coronary artery and vein anatomy