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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Shank3tm5.1Gfng
targeted mutation 5.1, Guoping Feng
MGI:5775650
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Shank3tm5.1Gfng/Shank3tm5.1Gfng involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J MGI:5776354
cn2
Shank3tm5.1Gfng/Shank3tm5.1Gfng
Tg(CAG-cre/Esr1*)1Lbe/0
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J MGI:5776355


Genotype
MGI:5776354
hm1
Allelic
Composition
Shank3tm5.1Gfng/Shank3tm5.1Gfng
Genetic
Background
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank3tm5.1Gfng mutation (1 available); any Shank3 mutation (85 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• decreased total distance travelled in open field test as compared to controls
• mice spend less time in open arm during elevated zero maze test as compared to controls
• repetitive grooming
• impaired motor coordination in rotarod test

nervous system
• decreased pop spike amplitude in the dorsal striatum as compared to controls
• presynaptic function, as determined by relationship of stimulation intensity to negative peak amplitude, is similar to control

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autism spectrum disorder DOID:0060041 J:229668




Genotype
MGI:5776355
cn2
Allelic
Composition
Shank3tm5.1Gfng/Shank3tm5.1Gfng
Tg(CAG-cre/Esr1*)1Lbe/0
Genetic
Background
involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shank3tm5.1Gfng mutation (1 available); any Shank3 mutation (85 available)
Tg(CAG-cre/Esr1*)1Lbe mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• prior to tamoxifen administration, mice exhibit decreased total distance travelled in open field test as compared to controls
• following tamoxifen administration, phenotype is unchanged
• prior to tamoxifen administration, mice spend less time in open arm during elevated zero maze test as compared to controls
• following tamoxifen administration at P20-21, mice exhibit reduced anxiety in the maze test
• tamoxifen administration in adult mice results in an unchanged phenotype
• prior to tamoxifen administration, mice exhibit repetitive grooming
• following tamoxifen administration, grooming is similar to control
• prior to tamoxifen administration, mice exhibit decreased latency to fall in rotarod test as compared to controls
• following tamoxifen administration at P20-21, mice perform significantly better on rotarod
• tamoxifen administration in adult mice results in an unchanged phenotype
• prior to tamoxifen administration, mice exhibit reduced rearing time and frequency as compared to controls
• following tamoxifen administration, phenotype is unchanged
• prior to tamoxifen administration, mice exhibit no preference for a stranger mouse or novel object in a test of voluntary social interaction
• following tamoxifen administration, mice exhibit a preference for a stranger mouse over a novel object in a test of voluntary social interaction

growth/size/body
• as compared to wild-type mice (no tamoxifen administered)

nervous system
• prior to tamoxifen administration, mice exhibit a reduction of spine density in medium spiny neurons as compared to controls
• following tamoxifen administration, spine density is increased to a greater density than controls
• prior to tamoxifen administration, mice exhibit a reduction of spine density in medium spiny neurons
• following tamoxifen administration, spine density is increased to a greater density than controls
• prior to tamoxifen administration, mice exhibit a reduced field population spikes in the dorsal striatum as compared to controls
• following tamoxifen administration, mice exhibit field responses similar to control
• prior to tamoxifen administration, mice exhibit a reduced mEPSC frequency as compared to controls
• following tamoxifen administration, mice exhibit mEPSC frequencies similar to control





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory