All Phenotypes Shank3<tm5.1Gfng> MGI Mouse

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder	DOID:0060041		J:229668

• prior to tamoxifen administration, mice exhibit decreased total distance travelled in open field test as compared to controls

• following tamoxifen administration, phenotype is unchanged

• prior to tamoxifen administration, mice spend less time in open arm during elevated zero maze test as compared to controls

• following tamoxifen administration at P20-21, mice exhibit reduced anxiety in the maze test

• tamoxifen administration in adult mice results in an unchanged phenotype

increased grooming behavior ( J:229668 )

• prior to tamoxifen administration, mice exhibit repetitive grooming

• following tamoxifen administration, grooming is similar to control

impaired coordination ( J:229668 )

• prior to tamoxifen administration, mice exhibit decreased latency to fall in rotarod test as compared to controls

• following tamoxifen administration at P20-21, mice perform significantly better on rotarod

• tamoxifen administration in adult mice results in an unchanged phenotype

decreased vertical activity ( J:229668 )

• prior to tamoxifen administration, mice exhibit reduced rearing time and frequency as compared to controls

• following tamoxifen administration, phenotype is unchanged

abnormal social investigation ( J:229668 )

• prior to tamoxifen administration, mice exhibit no preference for a stranger mouse or novel object in a test of voluntary social interaction

• following tamoxifen administration, mice exhibit a preference for a stranger mouse over a novel object in a test of voluntary social interaction

decreased body weight ( J:229668 )

• as compared to wild-type mice (no tamoxifen administered)

• prior to tamoxifen administration, mice exhibit a reduction of spine density in medium spiny neurons as compared to controls

• following tamoxifen administration, spine density is increased to a greater density than controls

• prior to tamoxifen administration, mice exhibit a reduction of spine density in medium spiny neurons

• following tamoxifen administration, spine density is increased to a greater density than controls

• prior to tamoxifen administration, mice exhibit a reduced field population spikes in the dorsal striatum as compared to controls

• following tamoxifen administration, mice exhibit field responses similar to control

• prior to tamoxifen administration, mice exhibit a reduced mEPSC frequency as compared to controls

• following tamoxifen administration, mice exhibit mEPSC frequencies similar to control

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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