Phenotypes associated with this allele

• Allele Symbol: Nptn^tm1.2Mtg
• Allele Name: targeted mutation 1.2, Dirk Montag
• Allele ID: MGI:5775785
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nptn^tm1.2Mtg/Nptn^tm1.2Mtg	involves: 129	MGI:5703728

Genotype
MGI:5703728

hm1

• Allelic Composition: Nptn^tm1.2Mtg/Nptn^tm1.2Mtg
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:212431 )

N • neuron survival is normal

decreased CNS synapse formation ( J:212431 )

• reduced CA1 and dentate gyrus excitatory synapses although CA3 synapse density is normal

• reduced numbers of synaptic contacts around dendrites and existing contacts are abnormal

• increased numbers of unmatched postsynaptic units

• presynapses in normal numbers

• GABAergic contacts unaffected

• 30% decrease in the ratio of excitatory to inhibitory synapses

abnormal dendritic spine morphology ( J:212431 )

abnormal CNS synaptic transmission ( J:212431 )

abnormal miniature excitatory postsynaptic currents ( J:212431 )

• peak amplitudes significantly reduced

abnormal miniature inhibitory postsynaptic currents ( J:212431 )

• reduced decay time but normal rise time

increased miniature inhibitory postsynaptic current amplitude ( J:212431 )

• increased peak amplitude but frequency unaffected