Analysis Tools
nervous system
microgliosis
(
J:232167
)
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• motor neuron degeneration is associated with astrocytosis and microgliosis
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astrocytosis
(
J:232167
)
|
• motor neuron degeneration is associated with astrocytosis and microgliosis
|
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• by P40, before motor neuron loss, a significant number of neuromuscular junctions in the tibialis anterior has no associated input, indicating early retraction of motor axons
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• loss of motor neurons at lumber level 5 (L5) is first seen at P60 and progresses steadily to P360
• however, no loss of parvalbumin-positive, proprioceptive sensory neurons in the L5 dorsal root ganglia is seen or of motor neuron loss in oculomotor nucleus at P360
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• by P40, denervation of the tibialis anterior neuromuscular junctions are seen before motor neuron loss
• denervation of the gastrocnemius muscle is seen at P90 when about 10% of neuromuscular junctions are vacant
• denervation in both the tibialis anterior and gastrocnemius muscles progresses steadily so that by P360, 30.2% and 13.9% of endplates are vacant in the respective muscles
• however, no denervation of the slow sloeus muscle is seen at 1 year
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hematopoietic system
microgliosis
(
J:232167
)
|
• motor neuron degeneration is associated with astrocytosis and microgliosis
|
immune system
microgliosis
(
J:232167
)
|
• motor neuron degeneration is associated with astrocytosis and microgliosis
|
