Phenotypes associated with this allele

• Allele Symbol: Fus^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:5776262
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fus^tm1c(EUCOMM)Wtsi/Fus^tm1c(EUCOMM)Wtsi	involves: C3H * C57BL/6 * C57BL/6N	MGI:5823863
cn2	Fus^tm1a(EUCOMM)Wtsi/Fus^tm1c(EUCOMM)Wtsi Mapt^tm3.1(FUS)Neas/Mapt^+ Ndor1^Tg(UBC-cre/ERT2)1Ejb/0	involves: 129 * C3H * C57BL/6 * C57BL/6N	MGI:5824116
cn3	Fus^tm1a(EUCOMM)Wtsi/Fus^tm1c(EUCOMM)Wtsi Chat^tm2(cre)Lowl/Chat^+	involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6N	MGI:5823868
cn4	Fus^tm1a(EUCOMM)Wtsi/Fus^tm1c(EUCOMM)Wtsi Ndor1^Tg(UBC-cre/ERT2)1Ejb/0	involves: 129S/SvEv * C3H * C57BL/6 * C57BL/6N	MGI:5824114

Genotype
MGI:5823863

hm1

• Allelic Composition: Fus^{tm1c(EUCOMM)Wtsi}/Fus^{tm1c(EUCOMM)Wtsi}
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6N
• Cell Lines: EPD0667_5_C04

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:232167 )

• mice exhibit normal postnatal survival

Genotype
MGI:5824116

cn2

• Allelic Composition: Fus^{tm1a(EUCOMM)Wtsi}/Fus^{tm1c(EUCOMM)Wtsi}; Mapt^{tm3.1(FUS)Neas}/Mapt⁺; Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0
• Genetic Background: involves: 129 * C3H * C57BL/6 * C57BL/6N
• Cell Lines: EPD0667_5_C04

nervous system

abnormal neuromuscular synapse morphology ( J:232167 )

• mice treated with tamoxifen postnatally show denervation in the tibialis anterior muscle where about 12% of neuromuscular junctions are denervated

Genotype
MGI:5823868

cn3

• Allelic Composition: Fus^{tm1a(EUCOMM)Wtsi}/Fus^{tm1c(EUCOMM)Wtsi}; Chat^tm2(cre)Lowl/Chat⁺
• Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/6N
• Cell Lines: EPD0667_5_C04

nervous system

nervous system phenotype ( J:232167 )

N • no motor neuron degeneration is seen up to 1 year of age

Genotype
MGI:5824114

cn4

• Allelic Composition: Fus^{tm1a(EUCOMM)Wtsi}/Fus^{tm1c(EUCOMM)Wtsi}; Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0
• Genetic Background: involves: 129S/SvEv * C3H * C57BL/6 * C57BL/6N
• Cell Lines: EPD0667_5_C04

nervous system

nervous system phenotype ( J:232167 )

N • no significant loss of lumbar level 5 motor neurons or denervation of the tibialis anterior muscle are seen at P240