Phenotypes associated with this allele

• Allele Symbol: Gsdmd^em3Fcw
• Allele Name: endonuclease-mediated mutation 3, Fengchao Wang
• Allele ID: MGI:5776362
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gsdmd^em3Fcw/Gsdmd^em3Fcw	involves: C57BL/6	MGI:5776374

Genotype
MGI:5776374

hm1

• Allelic Composition: Gsdmd^em3Fcw/Gsdmd^em3Fcw
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal macrophage apoptosis ( J:226781 )

• bone marrow-derived macrophages are resistant to LPS- or S. typhimurium-induced pyroptosis unlike wild-type cells

• however, cells are sensitive to TSZ- or LPS plus zVAD-induced necroptosis

hematopoietic system

abnormal macrophage apoptosis ( J:226781 )

• bone marrow-derived macrophages are resistant to LPS- or S. typhimurium-induced pyroptosis unlike wild-type cells

• however, cells are sensitive to TSZ- or LPS plus zVAD-induced necroptosis

immune system

abnormal macrophage apoptosis ( J:226781 )

• bone marrow-derived macrophages are resistant to LPS- or S. typhimurium-induced pyroptosis unlike wild-type cells

• however, cells are sensitive to TSZ- or LPS plus zVAD-induced necroptosis

decreased interleukin-1 beta secretion ( J:226781 )

• in response to NAIP2/5-NLRC4, NLRP3, Pyrin and AIM2 inflammasomes or S. typhimurium infection, bone marrow-derived macrophages secrete little Il1b compared with wild-type cells

• however, IL1B maturation in the cytosol is maintained