Phenotypes associated with this allele

• Allele Symbol: Brd4^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5776368
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brd4^tm1b(EUCOMM)Wtsi/Brd4^tm1b(EUCOMM)Wtsi	C57BL/6N-Brd4^tm1b(EUCOMM)Wtsi/Bay	MGI:6261997
ht2	Brd4^tm1b(EUCOMM)Wtsi/Brd4^+	C57BL/6N-Brd4^tm1b(EUCOMM)Wtsi/Bay	MGI:6288359

Genotype
MGI:6261997

hm1

• Allelic Composition: Brd4^{tm1b(EUCOMM)Wtsi}/Brd4^{tm1b(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Brd4^{tm1b(EUCOMM)Wtsi}/Bay
• Cell Lines: EPD0445_5_C02

Data Sources

IMPC Data for Brd4

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - BCM

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM

Genotype
MGI:6288359

ht2

• Allelic Composition: Brd4^{tm1b(EUCOMM)Wtsi}/Brd4⁺
• Genetic Background: C57BL/6N-Brd4^{tm1b(EUCOMM)Wtsi}/Bay
• Cell Lines: EPD0445_5_C02

Data Sources

IMPC Data for Brd4

behavior/neurological

increased grip strength ( J:211773 )

♂

IMPC - BCM

cardiovascular system

abnormal retina blood vessel morphology ( J:211773 )

♂

IMPC - BCM

craniofacial

abnormal cranium morphology ( J:211773 )

IMPC - BCM

limbs/digits/tail

short tibia ( J:211773 )

IMPC - BCM

nervous system

decreased prepulse inhibition ( J:211773 )

♀

IMPC - BCM

skeleton

abnormal cranium morphology ( J:211773 )

IMPC - BCM

short tibia ( J:211773 )

IMPC - BCM

vision/eye

abnormal retina blood vessel morphology ( J:211773 )

♂

IMPC - BCM

abnormal eye posterior chamber depth ( J:211773 )

♀

IMPC - BCM

abnormal retina inner nuclear layer morphology ( J:211773 )

IMPC - BCM

abnormal retina outer nuclear layer morphology ( J:211773 )

♀

IMPC - BCM

decreased total retina thickness ( J:211773 )

IMPC - BCM