Phenotypes associated with this allele

• Allele Symbol: Asb2^{tm2b(KOMP)Wtsi}
• Allele Name: targeted mutation 2b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5776369
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Asb2^tm2b(KOMP)Wtsi/Asb2^tm2b(KOMP)Wtsi	C57BL/6N-Asb2^tm2b(KOMP)Wtsi/Kmpc	MGI:6325113
ht2	Asb2^tm2b(KOMP)Wtsi/Asb2^+	C57BL/6N-Asb2^tm2b(KOMP)Wtsi/Kmpc	MGI:6325112

Genotype
MGI:6325113

hm1

• Allelic Composition: Asb2^{tm2b(KOMP)Wtsi}/Asb2^{tm2b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Asb2^{tm2b(KOMP)Wtsi}/Kmpc
• Cell Lines: EPD0477_1_D04

Data Sources

IMPC Data for Asb2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vitelline vasculature morphology ( J:211773 )

IMPC - KMPC

abnormal pericardium morphology ( J:211773 )

IMPC - KMPC

embryo

abnormal vitelline vasculature morphology ( J:211773 )

IMPC - KMPC

embryonic growth retardation ( J:211773 )

IMPC - KMPC

abnormal embryo size ( J:211773 )

IMPC - KMPC

pale yolk sac ( J:211773 )

IMPC - KMPC

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - KMPC

abnormal embryo size ( J:211773 )

IMPC - KMPC

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - KMPC

Genotype
MGI:6325112

ht2

• Allelic Composition: Asb2^{tm2b(KOMP)Wtsi}/Asb2⁺
• Genetic Background: C57BL/6N-Asb2^{tm2b(KOMP)Wtsi}/Kmpc
• Cell Lines: EPD0477_1_D04

Data Sources

IMPC Data for Asb2

adipose tissue

decreased total body fat amount ( J:211773 )

♂

IMPC - KMPC

cardiovascular system

abnormal retina blood vessel morphology ( J:211773 )

♂

IMPC - KMPC

hematopoietic system

increased eosinophil cell number ( J:211773 )

IMPC - KMPC

increased dendritic cell number ( J:211773 )

IMPC - KMPC

decreased Ly6C-positive immature NK cell number ( J:211773 )

IMPC - KMPC

increased NK cell number ( J:211773 )

IMPC - KMPC

increased Ly6C-positive immature NK cell number ( J:211773 )

IMPC - KMPC

increased Ly6C-positive mature NK cell number ( J:211773 )

IMPC - KMPC

decreased effector memory T-helper cell number ( J:211773 )

IMPC - KMPC

increased T cell number ( J:211773 )

IMPC - KMPC

increased CD4-positive, alpha-beta T cell number ( J:211773 )

♀

IMPC - KMPC

increased Ly6C-positive NK T cell number ( J:211773 )

IMPC - KMPC

homeostasis/metabolism

increased circulating aspartate transaminase level ( J:211773 )

♂

IMPC - KMPC

immune system

increased eosinophil cell number ( J:211773 )

IMPC - KMPC

increased dendritic cell number ( J:211773 )

IMPC - KMPC

decreased Ly6C-positive immature NK cell number ( J:211773 )

IMPC - KMPC

increased NK cell number ( J:211773 )

IMPC - KMPC

increased Ly6C-positive immature NK cell number ( J:211773 )

IMPC - KMPC

increased Ly6C-positive mature NK cell number ( J:211773 )

IMPC - KMPC

decreased effector memory T-helper cell number ( J:211773 )

IMPC - KMPC

increased T cell number ( J:211773 )

IMPC - KMPC

increased CD4-positive, alpha-beta T cell number ( J:211773 )

♀

IMPC - KMPC

increased Ly6C-positive NK T cell number ( J:211773 )

IMPC - KMPC

vision/eye

abnormal retina blood vessel morphology ( J:211773 )

♂

IMPC - KMPC