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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sprr3tm1.1Ppy
targeted mutation 1.1, Pampee P Young
MGI:5776399
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sprr3tm1.1Ppy/Sprr3tm1.1Ppy B6.Cg-Sprr3tm1.1Ppy MGI:5776476
cx2
 		Apoetm1Unc/Apoetm1Unc
Sprr3tm1.1Ppy/Sprr3tm1.1Ppy 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL MGI:5776478


Genotype
MGI:5776476
hm1
Allelic
Composition		 Sprr3tm1.1Ppy/Sprr3tm1.1Ppy
Genetic
Background		 B6.Cg-Sprr3tm1.1Ppy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sprr3tm1.1Ppy mutation (1 available); any Sprr3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:230470 )
• mice are overtly normal with normal weight, reproduction, and serum cholesterol and triglyceride levels




Genotype
MGI:5776478
cx2
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Sprr3tm1.1Ppy/Sprr3tm1.1Ppy
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Sprr3tm1.1Ppy mutation (1 available); any Sprr3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:230470 )
N
• endothelial cell survival and proliferation are normal
increased susceptibility to atherosclerosis ( J:230470 )
• 3-fold increase in lesion area in mice fed either normal chow or a high-fat diet compared to in Apoetm1Unc homozygotes
• increased susceptibility is not attributable to bone-marrow derived cells as determined by transplant experiments
vascular smooth muscle hypoplasia ( J:230470 )
• reduced lesion vascular smooth muscle cell (VSMC) content due to apoptosis whether fed standard chow or a high-fat diet compared with control mice
• however, disease-free arteries exhibit normal VSMC content
abnormal vascular smooth muscle physiology ( J:230470 )
• reduced lesion vascular smooth muscle cell (VSMC) content due to apoptosis whether fed standard chow or a high-fat diet compared with control mice
• vascular smooth muscle cells exhibit increased cellular sensitivity to hydrogen peroxide compared with control cells
• however, disease-free arteries exhibit normal VSMC apoptosis rates

cellular
increased cellular sensitivity to hydrogen peroxide ( J:230470 )
• in vascular smooth muscle cells

muscle
vascular smooth muscle hypoplasia ( J:230470 )
• reduced lesion vascular smooth muscle cell (VSMC) content due to apoptosis whether fed standard chow or a high-fat diet compared with control mice
• however, disease-free arteries exhibit normal VSMC content
abnormal vascular smooth muscle physiology ( J:230470 )
• reduced lesion vascular smooth muscle cell (VSMC) content due to apoptosis whether fed standard chow or a high-fat diet compared with control mice
• vascular smooth muscle cells exhibit increased cellular sensitivity to hydrogen peroxide compared with control cells
• however, disease-free arteries exhibit normal VSMC apoptosis rates




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory