Phenotypes associated with this allele

• Allele Symbol: Sorbs2^tm1.2Gfng
• Allele Name: targeted mutation 1.2, Guoping Feng
• Allele ID: MGI:5776502
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sorbs2^tm1.2Gfng/Sorbs2^tm1.2Gfng	B6.129(FVB)-Sorbs2^tm1.2Gfng	MGI:5776509

Genotype
MGI:5776509

hm1

• Allelic Composition: Sorbs2^tm1.2Gfng/Sorbs2^tm1.2Gfng
• Genetic Background: B6.129(FVB)-Sorbs2^tm1.2Gfng

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:231609 )

• 40-60% mortality in the first post natal week, however surviving mice appear normal

nervous system

abnormal dendrite morphology ( J:231609 )

• dendritic trees of dentate gyrus granule cells are less complex than controls

• total dendritic length is reduced

• number of dendritic branch points is reduced

abnormal miniature excitatory postsynaptic currents ( J:231609 )

• mean frequency of AMPAR-mediated mEPSC from dentate gyrus granule cells is reduced as compared to wild-type, however, amplitude is similar to controls

decreased prepulse inhibition ( J:231609 )

♂ • impaired performance in acoustic prepulse inhibition test (PPI)

behavior/neurological

behavior/neurological phenotype ( J:231609 )

♂N • performance in elevated zero maze test, open-field test, toned fear conditioning and Morris water maze tests is similar to controls in male mice (females not tested)

impaired contextual conditioning behavior ( J:231609 )

♂ • 24 hours after training mice exhibit less freezing time in contextual fear memory than controls

impaired long-term object recognition memory ( J:231609 )

♂ • initial response to novel object recognition is similar to controls, however after 24 hour delay mice show less preference for new object than controls

decreased startle reflex ( J:231609 )

♂ • reduced acoustic startle response