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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		tbyl
trembly lethal
MGI:5776521
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		tbyl/tbyl BALB/cByJ-tbyl/GrsrJ MGI:5776526


Genotype
MGI:5776526
hm1
Allelic
Composition		 tbyl/tbyl
Genetic
Background		 BALB/cByJ-tbyl/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
tbyl mutation (1 available); any tbyl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal myelination ( J:232317 )
• histology of one female and one male homozygote at 30 days of age found severe myelin deficiency in the brain and spinal cord

behavior/neurological
tremors ( J:232317 )
• whole-body tremor evident by 2 to 3 weeks of age and persists until death by 5 weeks of age

mortality/aging
lethality at weaning, complete penetrance ( J:232317 )
• all homozygotes die between 4 and 5 weeks of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory