All Phenotypes Atp6ap2<tm1.1Ics> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Atp6ap2^tm1.1Ics
targeted mutation 1.1, Mouse Clinical Institute
MGI:5776594

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atp6ap2^tm1.1Ics/Y	involves: C57BL/6 * C57BL/6N	MGI:5779964
cn2	Atp6ap2^tm1.1Ics/Y Tg(NPHS2-cre)295Lbh/0	involves: C57BL/6 * C57BL/6N * SJL	MGI:5779963

Allelic Composition	Atp6ap2^tm1.1Ics/Y
Genetic Background	involves: C57BL/6 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp6ap2^tm1.1Ics mutation (0 available); any Atp6ap2 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

impaired autophagy ( J:232697 )

• impaired in podocytes infected with a cre-expressing adenovirus

homeostasis/metabolism

impaired autophagy ( J:232697 )

• impaired in podocytes infected with a cre-expressing adenovirus

Allelic Composition	Atp6ap2^tm1.1Ics/Y Tg(NPHS2-cre)295Lbh/0
Genetic Background	involves: C57BL/6 * C57BL/6N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp6ap2^tm1.1Ics mutation (0 available); any Atp6ap2 mutation (10 available)
Tg(NPHS2-cre)295Lbh mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:232697 )

• between 2 and 3 weeks after birth

renal/urinary system

increased podocyte apoptosis ( J:232697 )

increased urine protein level ( J:232697 )

• by 14 days

albuminuria ( J:232697 )

• at P2

abnormal podocyte morphology ( J:232697 )

• impaired vacuolar acidification with abnormal cytoskeleton organization and cell death

podocyte foot process effacement ( J:232697 )

abnormal renal tubule epithelium morphology ( J:232697 )

• massive protein enrichment

absent proximal convoluted tubule brush border ( J:232697 )

dilated renal tubule ( J:232697 )

renal cast ( J:232697 )

• protein casts in renal tubules

homeostasis/metabolism

impaired autophagy ( J:232697 )

• impaired in podocytes

increased circulating creatinine level ( J:232697 )

• by 14 days

increased blood urea nitrogen level ( J:232697 )

• by 14 days

increased circulating cholesterol level ( J:232697 )

• by 14 days

decreased circulating serum albumin level ( J:232697 )

• by 14 days

increased urine protein level ( J:232697 )

• by 14 days

albuminuria ( J:232697 )

• at P2

cellular

abnormal cell cytoskeleton morphology ( J:232697 )

• impaired vacuolar acidification with abnormal cytoskeleton organization and cell death

impaired autophagy ( J:232697 )

• impaired in podocytes

increased podocyte apoptosis ( J:232697 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24