Phenotypes associated with this allele

• Allele Symbol: Clec12a^tm1Gdb
• Allele Name: targeted mutation 1, Gordon D Brown
• Allele ID: MGI:5779394
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clec12a^tm1Gdb/Clec12a^tm1Gdb	involves: C57BL/6	MGI:5779652

Genotype
MGI:5779652

hm1

• Allelic Composition: Clec12a^tm1Gdb/Clec12a^tm1Gdb
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to bacterial infection ( J:224869 )

• streptomycin-pretreated mice show increased susceptibility to infection with streptomycin resistant Salmonella enterica serovar Typhimurium SL1344, with significantly higher CFU levels in stool and spleen, and a more severe disease score as assessed by overall appearance, piloerection, mobility, posture, and decreased survival at 4 days post-infection (dpi) relative to wild-type controls

increased susceptibility to bacterial infection induced morbidity/mortality ( J:224869 )

• following infection with Salmonella enterica serovar Typhimurium SL1344, all streptomycin-pretreated mice die by 4 dpi, unlike wild-type controls which die by 9 dpi

cellular

abnormal autophagy ( J:224869 )

• following infection with Listeria monocytogenes EGDe, a strain susceptible to autophagy in primary macrophages, mutant bone-marrow-derived macrophages (BMDMs) show reduced levels of bacterial co-localization with LC3 relative to wild-type BMDMs, suggesting impaired antibacterial autophagy

• however, no differences are observed in autophagy induced by Torin 1, an inducer of bulk autophagy

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:224869 )

• following infection with Salmonella enterica serovar Typhimurium SL1344, all streptomycin-pretreated mice die by 4 dpi, unlike wild-type controls which die by 9 dpi

homeostasis/metabolism

abnormal autophagy ( J:224869 )

• following infection with Listeria monocytogenes EGDe, a strain susceptible to autophagy in primary macrophages, mutant bone-marrow-derived macrophages (BMDMs) show reduced levels of bacterial co-localization with LC3 relative to wild-type BMDMs, suggesting impaired antibacterial autophagy

• however, no differences are observed in autophagy induced by Torin 1, an inducer of bulk autophagy