Analysis Tools
behavior/neurological
| N |
• mice exhibit normal acoustic startle responses, sensorimotor gating in the prepulse inhibition assay, social interactions and cocaine-induced increase in locomotion, movement velocity and sensitization
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• blocked with reduced distance traveled in response to lithium
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• mice exhibit no preference for the cocaine-associated context unlike wild-type mice
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• on day 1 and 2
• however, freezing on day 3 was normal as was cued conditioning
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• in an elevated-plus maze
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• modest
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• in an open field
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nervous system
| N |
• mice exhibit normal inhibitory synapse density
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• partial reduction in density in medial prefrontal cortex (mPFC)
• however, synapse structure (postsynaptic density (PSD) length, PSD width, synaptic cleft width, presynaptic terminal area, terminal perimeter, number of vesicles per terminal, number of docked vesicles per terminal, vesicle density, or vesicle diameter) is normal
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