Phenotypes associated with this allele

• Allele Symbol: Tmx2^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5779820
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmx2^tm1.1(KOMP)Vlcg/Tmx2^tm1.1(KOMP)Vlcg	B6N(Cg)-Tmx2^tm1.1(KOMP)Vlcg/2J	MGI:6263731
hm2	Tmx2^tm1.1(KOMP)Vlcg/Tmx2^tm1.1(KOMP)Vlcg	C57BL/6N-Tmx2^tm1.1(KOMP)Vlcg/JMmucd	MGI:6376186

Genotype
MGI:6263731

hm1

• Allelic Composition: Tmx2^{tm1.1(KOMP)Vlcg}/Tmx2^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6N(Cg)-Tmx2^{tm1.1(KOMP)Vlcg}/2J
• Cell Lines: 10209A-A10

Data Sources

IMPC Data for Tmx2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:6376186

hm2

• Allelic Composition: Tmx2^{tm1.1(KOMP)Vlcg}/Tmx2^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Tmx2^{tm1.1(KOMP)Vlcg}/JMmucd
• Cell Lines: 10209A-A10

Tmx2^{tm1.1(KOMP)Vlcg}/Tmx2^{tm1.1(KOMP)Vlcg} mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as dying morulae. Mutants fail to hatch from the zona pellucida and never reach blastocyst stage in culture.

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at E3.5 (20% versus expected 25%, n=35) and appear to arrest/die prior to blastocyst formation; no embryos or excess resorption sites are observed at E7.5

embryo

failure of blastocyst formation ( J:279207 )

• in vitro, embryos never reach a morphological blastocyst stage

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro, embryos fail to hatch from the zona pellucida with apparent cell death after 3 days in culture

embryonic growth arrest ( J:279207 )

• morulas recovered at E3.5 appear to be dying

• embryos show no further development after 3 days in culture

abnormal morula morphology ( J:279207 )

• morulas recovered at E3.5 appear to be dying