Analysis Tools
neoplasm
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• mice develop extensive papillary thyroid carcinomas by 12 months of tamoxifen treatment, first showing enlarged follicles within 7 days of tamoxifen treatment, a squamous morphology of thyrocytes accompanied by a large increase in follicle size and loss of colloid by 14 days of tamoixfen treatment, and tumor cells with characteristic papillary structure by 6 months of tamoxifen administration
• occasionally localized tumor invasion into the surrounding muscle is seen, however frank metastasis to lymph nodes or distant organs is not observed
• although mice have palpable thyroid tumors by 13 months of tamoxifen treatment, mice are not overtly sick
• mice not treated with tamoxifen show regions of papillary thyroid cancer with adjacent histologically normal thyroid architecture at 12 months of age, however these mice exhibit normal TSH and T4 levels
• treatment with PD0325901, an MEK1/2 inhibitor, results in regression of papillary thyroid cancer in tamoxifen-administered mutants
• treatment with PD0325901 and T3 results in further papillary thyroid cancer regression in tamoxifen-administered mutants
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endocrine/exocrine glands
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• mice not treated with tamoxifen exhibit increased thyroid volume, however thyroid architecture is normal, indicating some leakiness of the cre transgene
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• within 7 days of tamoxifen treatment, mice show enlarged follicles throughout the entire gland
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• treatment with PD0325901 leads to decreased thyroid size of tamoxifen-administered mice
• tamoxifen treated mice develop an enlarged, goiterous, hypercellular thyroid that is up to 10 times larger than controls at 1 month and up to 300 times larger at 12 months after tamoxifen treatment
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• mice develop extensive papillary thyroid carcinomas by 12 months of tamoxifen treatment, first showing enlarged follicles within 7 days of tamoxifen treatment, a squamous morphology of thyrocytes accompanied by a large increase in follicle size and loss of colloid by 14 days of tamoixfen treatment, and tumor cells with characteristic papillary structure by 6 months of tamoxifen administration
• occasionally localized tumor invasion into the surrounding muscle is seen, however frank metastasis to lymph nodes or distant organs is not observed
• although mice have palpable thyroid tumors by 13 months of tamoxifen treatment, mice are not overtly sick
• mice not treated with tamoxifen show regions of papillary thyroid cancer with adjacent histologically normal thyroid architecture at 12 months of age, however these mice exhibit normal TSH and T4 levels
• treatment with PD0325901, an MEK1/2 inhibitor, results in regression of papillary thyroid cancer in tamoxifen-administered mutants
• treatment with PD0325901 and T3 results in further papillary thyroid cancer regression in tamoxifen-administered mutants
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• mice develop hypothyroidism by 1-3 months of tamoxifen treatment
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homeostasis/metabolism
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• mice exhibit a decrease in serum T4 levels at 1 and 3 months of tamoxifen treatment
• mice not treated with tamoxifen exhibit normal T4 levels
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• 100-fold increase in serum TSH levels at 1 and 3 months of tamoxifen treatment
• mice not treated with tamoxifen exhibit normal levels of TSH
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| papillary thyroid carcinoma | DOID:3969 |
OMIM:188550 |
J:172205 | |
