Analysis Tools
behavior/neurological
|
• increased time spent freezing at 1 hour retention period; freezing response is similar to wild-type at 1 day
|
|
• increased time spent freezing at one day cued fear memory retention test as compared to wild-type
|
|
• enhanced long term recognition memory - increased time investigating novel object at 24 hour and 3 day retention test
|
|
• more rapid fear extinction in contextual fear extinction paradigm and cued extinction learning as compared to wild-type
• mice exhibit decreased freezing response as early as second session (2 hours later) in contextual fear task and in subsequent exposures
• however, mice exhibit increased freezing 24 hours after training session as compared to wild-type
|
nervous system
|
• increase in 5 and 10 Hz induced LTP in slices from the CA1 region of the hippocampus as compared to wild-type
|
