Analysis Tools
integument
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• mice exhibit increased keratinocyte proliferation in the basal layer of back skin epidermis, as shown by Ki67 staining
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• mice exhibit periodical hair loss, similar to Ctsltm1Cptr homozygotes
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• mice exhibit epidermal hyperplasia with numerous proliferating cells, similar to Ctsltm1Cptr homozygotes
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• mice exhibit epidermal thickening, similar to Ctsltm1Cptr homozygotes
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immune system
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• mice exhibit a significantly decreased CD4+ T cell number in spleen relative to wild-type controls (5.5% versus 15.4%, respectively)
• splenic CD4+ T cell number is within the same range as in Ctsltm1Cptr homozygotes (4.2%)
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cellular
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• mice exhibit increased keratinocyte proliferation in the basal layer of back skin epidermis, as shown by Ki67 staining
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hematopoietic system
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• mice exhibit a significantly decreased CD4+ T cell number in spleen relative to wild-type controls (5.5% versus 15.4%, respectively)
• splenic CD4+ T cell number is within the same range as in Ctsltm1Cptr homozygotes (4.2%)
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