Phenotypes associated with this allele

• Allele Symbol: Nexn^tm1.1Zhh
• Allele Name: targeted mutation 1.1, Zouhair Aherrahrou
• Allele ID: MGI:5780982
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nexn^tm1.1Zhh/Nexn^tm1.1Zhh	involves: C57BL/6NTac	MGI:5780987
ht2	Nexn^tm1.1Zhh/Nexn^+	involves: C57BL/6NTac	MGI:5780988

Genotype
MGI:5780987

hm1

• Allelic Composition: Nexn^tm1.1Zhh/Nexn^tm1.1Zhh
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:228046 )

• many mice die in the first two days after birth

• nearly all mice die within 8 days after birth

• however, one mouse survived

cardiovascular system

abnormal heart morphology ( J:228046 )

• wall thinning at P6

• lower anterior and posterior wall thickness in diastole are lower than in wild-type mice

• however, sarcomeres are normal

increased heart weight ( J:228046 )

• 2.3-fold at P4

increased heart left ventricle size ( J:228046 )

• internal diameter in diastole and systole

dilated heart left ventricle ( J:228046 )

• rapidly progressive

cardiac fibrosis ( J:228046 )

• endomyocardial fibroelastosis

dilated cardiomyopathy ( J:228046 )

decreased cardiac muscle contractility ( J:228046 )

muscle

dilated cardiomyopathy ( J:228046 )

decreased cardiac muscle contractility ( J:228046 )

growth/size/body

increased heart weight ( J:228046 )

• 2.3-fold at P4

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypertrophic cardiomyopathy 20		DOID:0110326	OMIM:613876	J:228046

Genotype
MGI:5780988

ht2

• Allelic Composition: Nexn^tm1.1Zhh/Nexn⁺
• Genetic Background: involves: C57BL/6NTac

cardiovascular system

dilated cardiomyopathy ( J:228046 )

• to a lesser extent than homozygous mice

muscle

dilated cardiomyopathy ( J:228046 )

• to a lesser extent than homozygous mice