All Phenotypes Ddit3<tm1.1Irt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ddit3^tm1.1Irt
targeted mutation 1.1, Ira Tabas
MGI:5781019

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Apoe^tm1Unc/Apoe^tm1Unc Ddit3^tm1.1Irt/Ddit3^tm1.1Irt Tagln^tm2(cre)Yec/Tagln⁺	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J	MGI:5781094
cn2	Ddit3^tm1.1Irt/Ddit3^tm1.1Irt Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Tg(Mup3-Plau)350-2Eps/?	involves: C57BL/6 * DBA	MGI:5781097

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Ddit3^tm1.1Irt/Ddit3^tm1.1Irt Tagln^tm2(cre)Yec/Tagln⁺
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (33 available); any Apoe mutation (158 available)
Ddit3^tm1.1Irt mutation (1 available); any Ddit3 mutation (20 available)
Tagln^tm2(cre)Yec mutation (1 available); any Tagln mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:233223 )

• aortic root shows a approximate 30% reduction in lesion area and necrotic area compared to Apoe^tm1Unc Ddit3^tm1.1Irt double homozygotes, indicating decreased atherosclerotic plaque progression

• smooth muscle cell content is lower in aortic arch lesions compared to Ddit3^tm1.1Irt Apoe^tm1Unc double homozygotes

• mice on a Western diet show a lower content of alpha-actin-positive vascular smooth muscle cells in the lesions compared to Ddit3^tm1.1Irt Apoe^tm1Unc double homozygotes

• lesions show decreased vascular smooth muscle cell proliferation

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:233223 )

N	• after 12 weeks of Western diet feeding, mice exhibit similar body weight, blood glucose, total plasma cholesterol, HDL cholesterol, plasma triglycerides, and blood pressure as Apoe^tm1Unc Ddit3^tm1.1Irt double homozygotes

Allelic Composition	Ddit3^tm1.1Irt/Ddit3^tm1.1Irt Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Tg(Mup3-Plau)350-2Eps/?
Genetic Background	involves: C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddit3^tm1.1Irt mutation (1 available); any Ddit3 mutation (20 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)
Tg(Mup3-Plau)350-2Eps mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

increased hepatocellular carcinoma incidence ( J:233146 )

• mice fed a high fat diet develop hepatocellular carcinoma and show increased tumor multiplicity without affecting tumor size compared to single Tg(Mup3-Plau)350-2Eps transgenic mice

neoplasm

increased hepatocellular carcinoma incidence ( J:233146 )

• mice fed a high fat diet develop hepatocellular carcinoma and show increased tumor multiplicity without affecting tumor size compared to single Tg(Mup3-Plau)350-2Eps transgenic mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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