cellular
• morulas recovered at E3.5 appear to be dying
• morulas show no further development with apparent cell death after 3 days in culture
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embryo
• E3.5 embryos appear as dying morula
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• in culture, embryos fail to hatch from the zona pellucida with apparent cell death, never reaching a morphological blastocyst stage
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• morulas recovered at E3.5 appear to be dying
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mortality/aging
IMPC - JAX
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• homozygous embryos are recovered at lower than expected Mendelian ratios at E3.5 (8% versus 25%) and appear to arrest/die prior to blastocyst formation; no embryos or excess resorption sites are observed at E7.5
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IMPC - JAX
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