Phenotypes associated with this allele

• Allele Symbol: Thrb^tm1Ehs
• Allele Name: targeted mutation 1, National Institute of Environmental Health Science
• Allele ID: MGI:5784668
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thrb^tm1Ehs/Thrb^tm1Ehs	C57BL/6-Thrb^tm1Ehs	MGI:5791930

Genotype
MGI:5791930

hm1

• Allelic Composition: Thrb^tm1Ehs/Thrb^tm1Ehs
• Genetic Background: C57BL/6-Thrb^tm1Ehs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

impaired synaptic plasticity ( J:217014 )

• homozygotes show impaired maturation and plasticity of the Schaffer collateral synapses on CA1 pyramidal neurons in acutely isolated P12-P18 hippocampal slices

decreased excitatory postsynaptic current amplitude ( J:217014 )

• in response to Schaffer collateral stimulation, mice show a 50% reduction of EPSC amplitudes in CA1 pyramidal neurons at all stimulus intensities tested relative to wild-type controls

reduced long-term potentiation ( J:217014 )

• homozygotes fail to produce LTP in response to high-frequency stimulation of the Schaffer collaterals (two 1-sec periods of 100 Hz stimuli separated by 20 sec), unlike wild-type controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:217014 )

N • at 4 months of age, homozygotes are overtly normal with no differences in total circulating triiodothyronine (T3) and thyroxine (T4) levels relative to wild-type controls

N • thyroid hormone homeostasis and nuclear signaling by Thrb in the pituitary and liver remain normal