Phenotypes associated with this allele

• Allele Symbol: Mogat1^tm1Far
• Allele Name: targeted mutation 1, Bob Farese
• Allele ID: MGI:5785005
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mogat1^tm1Far/Mogat1^tm1Far	involves: 129S4/SvJae	MGI:5898247
cx2	Lep^ob/Lep^ob Mogat1^tm1Far/Mogat1^tm1Far	involves: 129S4/SvJae	MGI:5898250
cx3	Agpat2^tm1Garg/Agpat2^tm1Garg Mogat1^tm1Far/Mogat1^tm1Far	involves: 129S4/SvJae * 129S6/SvEvTac	MGI:5898249

Genotype
MGI:5898247

hm1

• Allelic Composition: Mogat1^tm1Far/Mogat1^tm1Far
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:231617 )

♀ • in female mice

♀ • however, male mice exhibit normal weight

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:231617 )

N • mice exhibit normal plasma triglyceride levels and consumption of oxygen and carbon dioxide

liver/biliary system

liver/biliary system phenotype ( J:231617 )

N • male and female mice exhibit normal liver triglyceride levels

Genotype
MGI:5898250

cx2

• Allelic Composition: Lep^ob/Lep^ob; Mogat1^tm1Far/Mogat1^tm1Far
• Genetic Background: involves: 129S4/SvJae

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:231617 )

N • mice exhibit normal metabolism

increased circulating glucose level ( J:231617 )

♀ • in female mice as in Lep^ob homozygotes

increased circulating insulin level ( J:231617 )

• in a meal tolerance test

increased circulating cholesterol level ( J:231617 )

• as in Lep^ob homozygotes

increased circulating triglyceride level ( J:231617 )

♀ • in female mice as in Lep^ob homozygotes

insulin resistance ( J:231617 )

• as in Lep^ob homozygotes

increased liver triglyceride level ( J:231617 )

• but not as much as in female mice as in Lep^ob homozygotes

liver/biliary system

increased liver triglyceride level ( J:231617 )

• but not as much as in female mice as in Lep^ob homozygotes

Genotype
MGI:5898249

cx3

• Allelic Composition: Agpat2^tm1Garg/Agpat2^tm1Garg; Mogat1^tm1Far/Mogat1^tm1Far
• Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:231617 )

N • mice exhibit normal plasma triglyceride, cholesterol levels, creatine kinase and creatinine level, and consumption of oxygen and carbon dioxide

increased circulating glucose level ( J:231617 )

♀ • in female, but not male, mice as in Agpat2^tm1Garg homozygotes

increased circulating insulin level ( J:231617 )

• during an oral glucose tolerance test whether fasted or not

improved glucose tolerance ( J:231617 )

♂ • male, but not female, mice exhibit increased glucose clearance compared with wild-type mice

insulin resistance ( J:231617 )

• hyperinsulinic-insulin resistant whether fasted or not

• however, mice exhibit normal glucose tolerance and normal insulin sensitivity in a meal tolerance test

increased liver triglyceride level ( J:231617 )

• in female and male mice as in Agpat2^tm1Garg homozygotes

liver/biliary system

increased liver weight ( J:231617 )

• in female and male mice at 16 weeks as in Agpat2^tm1Garg homozygotes

increased liver triglyceride level ( J:231617 )

• in female and male mice as in Agpat2^tm1Garg homozygotes

behavior/neurological

polydipsia ( J:231617 )

• in male and female mice as in Agpat2^tm1Garg homozygotes

increased food intake ( J:231617 )

♀ • in female, but not male, mice

growth/size/body

decreased body weight ( J:231617 )

• in female and male mice as in Agpat2^tm1Garg homozygotes

increased liver weight ( J:231617 )

• in female and male mice at 16 weeks as in Agpat2^tm1Garg homozygotes