Phenotypes associated with this allele

• Allele Symbol: Hcfc1^tm1Lwh
• Allele Name: targeted mutation 1, Winship Herr
• Allele ID: MGI:5787629
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Alb^tm1(cre/ERT2)Mtz/Alb^+ Hcfc1^tm1Lwh/Hcfc1^+	involves: 129S2/SvPas * C57BL/6	MGI:5901756
cn2	Hcfc1^tm1Lwh/Y Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: C57BL/6 * CBA	MGI:5901759
cn3	Hcfc1^tm1Lwh/Hcfc1^+ Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: C57BL/6 * CBA	MGI:5901761
cn4	Hcfc1^tm1Lwh/Hcfc1^tm1Lwh Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: C57BL/6 * CBA	MGI:5901762

Genotype
MGI:5901756

cn1

• Allelic Composition: Alb^{tm1(cre/ERT2)Mtz}/Alb⁺; Hcfc1^tm1Lwh/Hcfc1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

impaired liver regeneration ( J:231596 )

♀ • after induction with tamoxifen and partial hepatectomy, Hcfc1-negative cells do not display cell proliferation markers

Genotype
MGI:5901759

cn2

• Allelic Composition: Hcfc1^tm1Lwh/Y; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: C57BL/6 * CBA

embryo

decreased embryo size ( J:231596 )

♂ • at E9.5 male embryos much smaller in size and morphologically abnormal

growth/size/body

decreased embryo size ( J:231596 )

♂ • at E9.5 male embryos much smaller in size and morphologically abnormal

mortality/aging

embryonic lethality prior to organogenesis ( J:231596 )

♂ • male embryos died between E5.5 and E9.5

♂ • at E12.5 male embryos found at resorption sites

embryonic lethality, complete penetrance ( J:231596 )

♂ • no males born

Genotype
MGI:5901761

cn3

• Allelic Composition: Hcfc1^tm1Lwh/Hcfc1⁺; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: C57BL/6 * CBA

cellular

increased apoptosis ( J:231596 )

♀ • in E7.5 embryos with maternally inherited conditional knockout allele

decreased cell proliferation ( J:231596 )

♀ • reduced presence of cell proliferation markers in E7.5 embryos with maternally inherited conditional knockout allele

embryo

abnormal embryo morphology ( J:231596 )

♀ • of E7.5 embryos with maternally inherited conditional knockout allele

decreased embryo size ( J:231596 )

♀ • of E7.5 embryos with maternally inherited conditional knockout allele

abnormal extraembryonic tissue morphology ( J:231596 )

♀

growth/size/body

decreased embryo size ( J:231596 )

♀ • of E7.5 embryos with maternally inherited conditional knockout allele

decreased lean body mass ( J:231596 )

♀ • in females with a maternally inherited conditional knockout allele

decreased body length ( J:231596 )

♀ • in females with maternally inherited conditional knockout allele

mortality/aging

embryonic lethality prior to organogenesis ( J:231596 )

♀ • no female embryos with maternally inherited conditional knockout allele found at E7.5

embryonic lethality, complete penetrance ( J:231596 )

♀ • no females born with maternally inherited conditional knockout allele

♀ • females with paternally inherited conditional knockout allele viable

Genotype
MGI:5901762

cn4

• Allelic Composition: Hcfc1^tm1Lwh/Hcfc1^tm1Lwh; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: C57BL/6 * CBA

cellular

increased apoptosis ( J:231596 )

♀ • in E7.5 embryos

decreased cell proliferation ( J:231596 )

♀ • reduced presence of cell proliferation markers in E7.5 embryos

embryo

abnormal embryo morphology ( J:231596 )

♀ • of E7.5 embryos

decreased embryo size ( J:231596 )

♀ • of E7.5 embryos

abnormal extraembryonic tissue morphology ( J:231596 )

♀

growth/size/body

decreased embryo size ( J:231596 )

♀ • of E7.5 embryos

mortality/aging

embryonic lethality prior to organogenesis ( J:231596 )

♀ • no female embryos found at E7.5

embryonic lethality, complete penetrance ( J:231596 )

♀ • no females born