Phenotypes associated with this allele

• Allele Symbol: Mfap4^tm1Ascr
• Allele Name: targeted mutation 1, Anders Schlosser
• Allele ID: MGI:5787993
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mfap4^tm1Ascr/Mfap4^tm1Ascr	B6.129S1-Mfap4^tm1Ascr	MGI:5787999

Genotype
MGI:5787999

hm1

• Allelic Composition: Mfap4^tm1Ascr/Mfap4^tm1Ascr
• Genetic Background: B6.129S1-Mfap4^tm1Ascr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung morphology ( J:232534 )

♀ • female, but not male, mice exhibit increased distal air spaces compared with wild-type mice

abnormal pulmonary alveolar parenchyma morphology ( J:232534 )

♀ • female, but not male, mice exhibit decreased lung parenchyma density with increased low-attenuation area compared with wild-type mice

decreased lung elastance ( J:232534 )

♀ • in female, but not male, mice at 8 months

increased total lung capacity ( J:232534 )

♀ • in female, but not male, mice at 3 and 8 months

♀ • however, measurements at 6 months were not significance

abnormal respiratory function ( J:232534 )

♀ • increased expiratory reserve volume in female, but not male, mice at 3 and 6 months compared with wild-type mice

♀ • increased hysteresis in female, but not male, mice at 8 months compared with wild-type mice

♀ • however, mice exhibit normal functional residual capacity, vital capacity, volume od dead space, alveolar capillary gas exchange, and resistance

increased lung compliance ( J:232534 )

♀ • increased dynamic and static compliance in female, but not male, mice at 8 months compared with wild-type mice