Phenotypes associated with this allele

• Allele Symbol: Agbl4^{Tn(pb-Act-RFP)1.080115015-HRAZhu}
• Allele Name: transposon insertion 1.080115015-HRA, Yuan Zhuang
• Allele ID: MGI:5788002
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agbl4^Tn(pb-Act-RFP)1.080115015-HRAZhu/Agbl4^Tn(pb-Act-RFP)1.080115015-HRAZhu	involves: FVB/N	MGI:5897863

Genotype
MGI:5897863

hm1

• Allelic Composition: Agbl4^{Tn(pb-Act-RFP)1.080115015-HRAZhu}/Agbl4^{Tn(pb-Act-RFP)1.080115015-HRAZhu}
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:231311 )

• following herpes simplex virus (HSV) infection, mice exhibit increased mortality compared with wild-type mice

increased susceptibility to Poxviridae infection induced morbidity/mortality ( J:231311 )

• following vaccinia virus (VACV) infection, mice exhibit increased mortality compared with wild-type mice

hematopoietic system

hematopoietic system phenotype ( J:233744 )

N • mice exhibit normal red blood cell, white blood cell, hematopoietic stem cell, myeloid progenitor, common lymphoid progenitor, common myeloid progenitor, granulocyte/macrophage progenitor and megakaryocyte/erythroid progenitor counts and no defects of coagulation factors and fibrinogens

abnormal megakaryocyte morphology ( J:233744 )

• smaller size with weaker VWF signals

• poorly developed invaginated membrane system

abnormal megakaryocyte differentiation ( J:233744 )

• underdeveloped megakaryocytes

• extramedullary myelopoiesis in the spleen

• impaired maturation in the bone marrow

increased megakaryocyte cell number ( J:233744 )

• in the spleen and bone marrow

• accumulation of immature megakaryocytes in the bone marrow

abnormal platelet morphology ( J:233744 )

• elevated plateletcrit

• however, wild-type bone marrow cells transplanted into mice rescues platelet counts and function

abnormal platelet alpha-granule morphology ( J:233744 )

• decreased numbers and many vacuoles

decreased platelet alpha-granule number ( J:233744 )

thrombocytosis ( J:233744 )

abnormal platelet shape ( J:233744 )

• elevated platelet distribution width

abnormal spleen morphology ( J:233744 )

• disordered architecture

increased spleen weight ( J:233744 )

abnormal platelet physiology ( J:233744 )

• defective spreading

decreased platelet aggregation ( J:233744 )

• in response to ADP treatment and several agonists

• however, wild-type bone marrow cells transplanted into mice rescues platelet counts and function

homeostasis/metabolism

abnormal hemostasis ( J:233744 )

abnormal platelet physiology ( J:233744 )

• defective spreading

decreased platelet aggregation ( J:233744 )

• in response to ADP treatment and several agonists

• however, wild-type bone marrow cells transplanted into mice rescues platelet counts and function

increased bleeding time ( J:233744 )

cellular

abnormal megakaryocyte differentiation ( J:233744 )

• underdeveloped megakaryocytes

• extramedullary myelopoiesis in the spleen

• impaired maturation in the bone marrow

immune system

abnormal spleen morphology ( J:233744 )

• disordered architecture

increased spleen weight ( J:233744 )

increased susceptibility to Herpesvirales infection ( J:231311 )

• following herpes simplex virus (HSV) infection, mice exhibit increased mortality and viral load with decreased IFN alpha and beta compared with wild-type mice

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:231311 )

• following herpes simplex virus (HSV) infection, mice exhibit increased mortality compared with wild-type mice

increased susceptibility to Poxviridae infection ( J:231311 )

• following vaccinia virus (VACV) infection, mice exhibit increased mortality and viral load with decreased IFN alpha and beta compared with wild-type mice

increased susceptibility to Poxviridae infection induced morbidity/mortality ( J:231311 )

• following vaccinia virus (VACV) infection, mice exhibit increased mortality compared with wild-type mice

growth/size/body

increased spleen weight ( J:233744 )