Phenotypes associated with this allele

• Allele Symbol: Traj18^tm1.1Kro
• Allele Name: targeted mutation 1.1, Mitchell Kronenberg
• Allele ID: MGI:5788003
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Traj18^tm1.1Kro/Traj18^tm1.1Kro	involves: C57BL/6NTac	MGI:5788007

Genotype
MGI:5788007

hm1

• Allelic Composition: Traj18^tm1.1Kro/Traj18^tm1.1Kro
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

absent NK T cells ( J:232957 )

• mice lack invariant NK T cells

abnormal circulating interleukin-4 level ( J:232957 )

• not produced in alpha-galactosyl ceramide-injected mice unlike wild-type mice

abnormal interferon-gamma secretion ( J:232957 )

• not produced in alpha-galactosyl ceramide-injected mice unlike wild-type mice

decreased inflammatory response ( J:232957 )

• in an ovalbumin-induced model of lung inflammation, no eosinophils are detected in bronchoalveolar fluid with fewer neutrophils and total leukocytes compared with wild-type mice

respiratory system

decreased airway resistance ( J:232957 )

• in response to methacholine challenge 48 h after the final ovalbumin challenge or cockroach antigen model

homeostasis/metabolism

abnormal circulating interleukin-4 level ( J:232957 )

• not produced in alpha-galactosyl ceramide-injected mice unlike wild-type mice

hematopoietic system

absent NK T cells ( J:232957 )

• mice lack invariant NK T cells